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OPLL pp 29-37 | Cite as

Pathogenesis of Ossification of the Spinal Ligaments

  • Sumio Goto
  • Masashi Yamazaki

Abstract

Ossification of the posterior longitudinal ligament (OPLL), which was first reported in an autopsy case by Tsukimoto in 1960 [1] and was named by Terayama in 1964, and ossification of the yellow ligament (OYL) are frequently complicated by ossification of other ligaments; they have therefore been recognized as conditions associated with ankylosing spinal hyperostosis (ASH; Forestier and Lagier 1971 [2]) and diffuse idiopathic skeletal hyperostosis (DISH; Resnick et al. 1975 [3]). However, unlike ASH and DISH, OPLL and OYL are characterized by the ossification of ligaments in the spinal canal and a high incidence of severe myelopathy, and are therefore often classified together as a distinct category, “ossification of the spinal ligaments” (OSL).

Keywords

Cervical Spine Posterior Longitudinal Ligament Diffuse Idiopathic Skeletal Hyperostosis Wide Type Anterior Longitudinal Ligament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Tsukimoto H (1960) On an autopsied case of compression myelopathy with a callus formation in the cervical spinal canal (in Japanese). Nihon Geka Hokan (Arch Jpn Chir) 29: 1003Google Scholar
  2. 2.
    Forestier J, Lagier R (1971) Ankylosing hyperostosis of the spine. Clin Orthop 74: 65–83PubMedGoogle Scholar
  3. 3.
    Resnick D, Shaul SR, Robins JM (1975) Diffuse idiopathic skeletal hyperostosis (DISH): Forestier’s diseases with extraspinal manifestations. Radiology 115: 513–524Google Scholar
  4. 4.
    Ueyama K, Harata S, Itoh J, Nitobe T, Morikawa Y, Yamada S, Tornita T, Tian W, Rong G, Jia Y, Dang G, Cai Q, Liu S (1995) Epidemiologic study of ossification of the cervical posterior longitudinal ligament in China (in Japanese). In: Investigation committee report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare. Ministry of Public Health and Welfare, Kagoshima, pp 16–17Google Scholar
  5. 5.
    Terayama K (1988) Pathology of ossification of the posterior longitudinal ligament (in Japanese). J Jpn Orthop Assoc 85–101Google Scholar
  6. 6.
    Ohtsuka K, Terayama K, Yanagihara M, Wada K, Kasuga K (1986) An epidemiological survey on ossification of ligaments in the cervical and thoracic spine in individuals over 50 years of age. J Jpn Orthop Assoc 60: 1087–1098Google Scholar
  7. 7.
    Satou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S (1991) Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 16: 1249–1252CrossRefGoogle Scholar
  8. 8.
    Yamaguchi M, Sakou T, Taketomi E, Matsunaga S, Imamura T, Koga K, Hayashi K (1993) HLA haplotype of OPLL (in Japanese). Orthop Surg 44: 999–1002Google Scholar
  9. 9.
    Taketomi E, Sakoh T, Matsunuga S, Yamaguchi M (1992) Family study of a twin with ossification of the posterior longitudinal ligament in the cervical spine. Spine 17: S56 - S57CrossRefGoogle Scholar
  10. 10.
    Miura Y, Kawai K (1993) Genetic studies for OPLL; analysis of twin (in Japanese). Orthop Surg 44: 993–998Google Scholar
  11. 11.
    Terayama K (1989) Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 14: 1184–1191PubMedCrossRefGoogle Scholar
  12. 12.
    Ono K, Ota H, Tada K, Hamada H, Takaoka K (1977) Ossified posterior longitudinal ligament: a clinicopathologic study. Spine 2: 126–138CrossRefGoogle Scholar
  13. 13.
    Goto S (1981) Studies of ossification of the posterior longitudinal ligament in the cervical spine using microradiography and histochemistry (in Japanese). J Jpn Orthop Assoc 55: 451–466Google Scholar
  14. 14.
    Tsuzuki N, Imai T, Hotta Y (1981) Histopathological findings of the ossification of the posterior longitudinal ligament of the cervical spine and their significance (in Japanese). J Jpn Orthop Assoc 55: 387–397Google Scholar
  15. 15.
    Goto S (1979) Pathology on ossification of posterior longitudinal ligament in the cervical spine (in Japanese). Clin Orthop Surg 14: 1175–1184Google Scholar
  16. 16.
    Goto S (1987) Pathogenesis of ossification of spinal ligaments (in Japanese). Seikei Geka (Orthop Surg) 50: 131–145Google Scholar
  17. 17.
    Nakamura H (1994) A radiographic study of the progression of ossification of the cervical posterior longitudinal ligament: the correlation between the ossification of the posterior longitudinal ligament and that of the anterior longitudinal ligament (in Japanese). J Jpn Orthop Assoc 68: 725–736Google Scholar
  18. 18.
    Seki H, Tsuyama N, Hayashi K, Kurokawa T, Imai S, Yamabe N, Nakajima M (1974) Clinical examination of 185 cases of ossification of the posterior longitudinal ligament (in Japanese). Orthop Surg 25: 704–710Google Scholar
  19. 19.
    Terayama K (1976) Ossification of the posterior longitudinal ligament (in Japanese). J Jpn Orthop Assoc 50: 415–442Google Scholar
  20. 20.
    Saito Y, Inoue S, Goto S (1986) A roentgenographic study of spinal hyperostosis: the relationship between location of ligamentous ossification and posture. In: Bone morphometry, vol 6. Quantitative analysis of bone (in Japanese). Nishimura Shoten, Niigata, Japan, pp 80–86Google Scholar
  21. 21.
    Okada Y, Motegi M, Umeda Y, Tabe S, Yamamoto M, Okajima Y, Fujita R, Furufu T, Higashi T (1980) Radiological study on enlargement of ossification of the posterior longitudinal ligament of the cervical spine; from inclination angle of the cervical intervertebral joints (in Japanese). Orthop Surg 31: 1761–1773Google Scholar
  22. 22.
    Ishida Y (1988) Studies on induction mechanism of ossification of the posterior longitudinal ligament of the spine: especially on the cultured cells from the human spinal ligament (in Japanese). J Jpn Orthop Assoc 62: 1019–1027Google Scholar
  23. 23.
    Terakado A, Tagawa M, Goto S, Yamazaki M, Moriya H, Fujimura S (1995) Elevation of alkaline phosphatase activity induced by parathyroid hormone in osteoblast-like cells from the spinal hyperostotic mouse TWY (twy/twy). Calcif Tissue Int 56: 135–139PubMedCrossRefGoogle Scholar
  24. 24.
    Oda J, Tsuzuki N, Takahashi K (1993) Histology of cervical OPLL relationship between OPLL and intervertebral disc (in Japanese). Orthop Surg 44: 1033–1040Google Scholar
  25. 25.
    Yamazaki A, Homma T, Ishikawa S, Okumura H (1991) Magnetic resonance imaging and histologic study of hypertrophic cervical posterior longitudinal ligament: a case report. Spine 16: 1262–1266PubMedCrossRefGoogle Scholar
  26. 26.
    Yoshikawa S, Shiba M, Suzuki A (1968) Spinal-cord compression in untreated adult cases of vitamin-D resistant rickets. J Bone Joint Surg Am 50A: 743–752PubMedGoogle Scholar
  27. 27.
    Goto S (1982) Biochemical and histological studies on factors associated with bone metabolism and mechanical factors causing ossification of the longitudinal posterior ligament (in Japanese). Orthop Surg (suppl) 2: 80–90Google Scholar
  28. 28.
    Wada A (1995) Affinity of estrogen binding in the cultured spinal ligament cells: an in vitro study using cells from spinal ligament of ossification patients (in Japanese). J Jpn Orthop Assoc 69: 440–449Google Scholar
  29. 29.
    Okada Y, Motegi M, Fujita R, Furufu T, Sakamoto M, Tabe S (1987) Relationship between ossification of spinal ligaments and sex hormones (in Japanese). Seikei Geka (Orthop Surg) 50: 152–163Google Scholar
  30. 30.
    Goto S, Tanno T (1989) Study for bone mass in osteoporosis and hyperotosis (in Japanese). J Musculoskel Syst 2: 976–985Google Scholar
  31. 31.
    Ikegawa S (1993) Growth hormone (GH) and GH-associated growth factors in ossification of the posterior longitudinal ligament of the spine (in Japanese). Orthop Surg 44: 1008–1011Google Scholar
  32. 32.
    Hoshino Y, Kurokawa T, Iizuka T, Kamura S, Takuwa Y, Ogata E, Matsumoto T, Takeuchi Y (1987) Calcium metabolism in patients with ossification of the spinal ligaments (in Japanese). Seikei Geka (Orthop Surg) 50: 146–151Google Scholar
  33. 33.
    Ishizawa N (1992) Experimental study of hyperostosis induced by hyper-vitaminosis A (in Japanese). J Jpn Orthop Assoc 66: 919–930Google Scholar
  34. 34.
    Goto S, Inoue S, Kurihara M, Ogata S, Saito Y, Sato M, Shimo R (1986) Clinical and basic examination of hyperostosis and osteoporosis: differences and similarities. In: Bone morphometry, vol 6. Quantitative analysis of bone (in Japanese). Nishimura Shoten, Niigata, Japan, pp 131–139Google Scholar
  35. 35.
    Kawagishi T, Harada M (1979) Epidemiologic study on ossification of the posterior longitudinal ligament in diabetic patients (in Japanese). Clin Orthop Surg 14: 718–722Google Scholar
  36. 36.
    Takeuchi Y, Matsumoto T, Takuwa Y, Hoshino Y, Kurokawa T, Shibuya N, Ogata E (1989) High incidence of obesity and elevated serum immunoreactive insulin level in patients with paravertebral ligamentous ossification: a relationship to the development of ectopic ossification. J Bone Miner Metab 7: 17–21CrossRefGoogle Scholar
  37. 37.
    Tanno T, Moriya H, Goto S, Nagase J, Saito Y (1990) Study on glucose metabolism in patients with ankylosing spinal hyperostosis (in Japanese). Orthop Surg 41: 1121–1125Google Scholar
  38. 38.
    Kawaguchi H, Kurokawa T, Hoshino Y, Kawahara H, Ogata E, Matsumoto T (1992) Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-(3 in the ossification of the posterior longitudinal ligament of the cervical spine. Spine 17: S33 - S36PubMedCrossRefGoogle Scholar
  39. 39.
    Miyamoto S, Yonenobu K, Ono K (1993) Immunohistochemical demonstration of transforming growth factor-13, fibronectin and alkaline phosphatase in the ossified spinal ligaments (in Japanese). Orthop Surg 44: 1048–1055Google Scholar
  40. 40.
    Tanno T (1992) Experimental study on the spinal lesions in hyperostotic mouse (twy/twy): special reference to the pathogenesis of the ossification of the spinal ligaments and to the action of ethane-l-hydroxy-1,1-diphosphonate (EHDP) (in Japanese). J Jpn Orthop Assoc 66: 1073–1082Google Scholar
  41. 41.
    Goto S (1979) Pathology of ossification of the posterior longitudinal ligament (in Japanese). J Jpn Orthop Assoc 53: 1133–1135Google Scholar
  42. 42.
    Hirai N, Ikata T, Murase M, Morita T, Yamada H, Okada Y, Miyake R, Tachibana K, Kasai Y (1994) Bone mineral density of the lumbar spine in patients with ossification of cervical posterior longitudinal ligament (in Japanese). In: Investigation committee report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare. Ministry of Public Health and Welfare, Kagoshima, pp 9–11Google Scholar
  43. 43.
    Mamada T, Hoshino Y, Ohnishi I, Seichi A, Saita K, Kurokawa T (1993) Relationship between age and bone mineral density of each part of patients with OPLL (in Japanese). In: Investigation committee report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare. Ministry of Public Health and Welfare, Kagoshima, pp 13–17Google Scholar
  44. 44.
    Maezumi H (1990) Bone mineral analysis in patients with ossification of the posterior longitudinal ligament of the spine (in Japanese). J Jpn Orthop Assoc 64: 534–545Google Scholar
  45. 45.
    Tei J (1985) Roentgenological and quantitative micro-radiographic study on ossification of posterior longitudinal ligament (in Japanese). J Jpn Orthop Assoc 59: 153–166Google Scholar
  46. 46.
    Miura Y, Tanaka S, Hikone R (1993) Ossification of the spinal ligaments in Zuker fatty rat (in Japanese). Orthop Surg 44: 1107–1113Google Scholar
  47. 47.
    Goto S, Tanno T, Yamazaki M, Saito Y, Kobayashi Y, Sodeyama T, Terakado J, Yamakoshi H, Tagawa M, Nagai Y (1992) Recent advance of the study on pathogenesis of ossification of spinal ligament (in Japanese). In: Investigation committee report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare. Ministry of Public Health and Welfare, Tokyo, pp 431–444Google Scholar
  48. 48.
    Yamazaki M, Moriya H, Goto S, Saitoh Y, Arai K, Nagai Y (1991) Increased type IX collagen expression in the spinal hyperostotic mouse (twy/twy). Calcif Tissue Int 48: 182–189CrossRefGoogle Scholar
  49. 49.
    Kobayashi Y, Goto S, Yamazaki M, Hyakutake S, Kita T, Sodeyama T, Terakado J, Tanno T, Moriya H (1993) Bone mineral analysis in ossification of the posterior longitudinal ligament (in Japanese). In: Investigation commitee report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare. Ministry of Public Health and Welfare, Kagoshima, pp 18–21Google Scholar

Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Sumio Goto
    • 1
  • Masashi Yamazaki
    • 1
  1. 1.Department of Orthopaedic SurgeryChiba University School of MedicineChiba, 260Japan

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