Advertisement

OPLL pp 19-25 | Cite as

Genetic Background of Ossification of the Posterior Longitudinal Ligament

  • Shunji Matsunaga
  • Takashi Sakou
  • Hiroshi Uehara
  • Masao Yamaguchi
  • Hiroaki Koga
  • Kyouji Hayashi

Abstract

Ossification of the posterior longitudinal ligament (OPLL) has been widely recognized in recent years. Numerous studies have been carried out, chiefly by the Investigation Committe on Ossification of the Spinal Ligaments organized by the Japanese Ministry of Public Health and Welfare since 1975 to clarify the etiology of OPLL. The pathogenesis of this disease remains unknown. However, the recent genetic studies on this disease [1–5] have contributed to clarifying the pathogenesis. Human leukocyte antigen (HLA) haplotype analysis provides a useful means for studying the genetic background of diseases.

Keywords

Cervical Spine Human Leukocyte Antigen Bone Morphogenetic Protein Posterior Longitudinal Ligament Blood Relative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S (1991) Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 6: 1249–1252CrossRefGoogle Scholar
  2. 2.
    Terayama K, Wada K, Ohtsuka K, Tsuyama N, Kurokawa T, Ohtani K, Yamauchi H, Yamaura I, Miura S, Kaneda S, Harata S, Kokubun S, Inoue S, Motegi M, Miyazaki K, Ono K, Kataoka O, Ikata T, Hattori M, Sakou T, Furusho T (1984) Genetic study of the family of patients with ossification of the posterior longitudinal ligament in the cervical spine (in Japanese). In: Investigation committee 1983 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 17–23Google Scholar
  3. 3.
    Terayama K (1987) Family study of ossification of the posterior longitudinal ligament (in Japanese). In: Investigation committee 1986 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 10–11Google Scholar
  4. 4.
    Terayama K (1989) Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 14: 1184–1191PubMedCrossRefGoogle Scholar
  5. 5.
    Matsunaga S, Sakou T, Taketomi E, Yamaguchi M, Hayashi K, Koga H (1993) Ossification of the spinal ligament and human leukocyte antigen haplotype (in Japanese). Spine Spinal Cord 6: 781–785Google Scholar
  6. 6.
    Tsuyama N, Hoshino Y, Kurokawa T, Tanaka H, Kobayashi M, Nakamura K, Machida H, Iizuka T, Satake M, Juji T (1983) Ossification of the posterior longitudinal ligament and HLA (in Japanese). In: Investigation committee 1982 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 17–19Google Scholar
  7. 7.
    Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloh MA, Kaplan FS (1992) A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP 5, BMP 6 and BMP 7. Genomics 14: 759–762PubMedCrossRefGoogle Scholar
  8. 8.
    Horimi T, Sasano Y, Ninomiya M (1984) A new method for isolation and purification of peripheral lymphocytes by using Lympho-Kwik (in Japanese). Transplantation 14: 321–326Google Scholar
  9. 9.
    Terasaki PI, Bernoco D, Park MS, Ozturk G, Iwaki Y (1978) Microdroplet testing for HLA-A,B,C antigens. Am J Clin Pathol 69: 103–120PubMedGoogle Scholar
  10. 10.
    Fujii Y, Juji T, Kaibara N (1983) Family study of HLA- A,B,C and DR in Japanese. Transplantation 18: 189–203Google Scholar
  11. 11.
    Uehara H, Sakou T, Taketomi K, Matsunaga S, Yamaguchi M (1994) Familial study of hereditary factor for the ossification of the posterior longitudinal ligament (in Japanese). Seikeigeka (Orthop Surg) 45: 1341–1345Google Scholar
  12. 12.
    Taketomi E, Sakou T, Matsunaga S, Yamaguchi M (1992) Family study of a twin ossification of the posterior longitudinal ligament in the cervical spine. Spine 17: S55 - S56PubMedCrossRefGoogle Scholar
  13. 13.
    Koga H, Hayashi K, Taketomi E, Matsunaga S, Sakou T (1996) Restriction fragment length polymorphism of gene of a2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase and tumor necrosis factor-a among ossification of posterior longitudinal ligament patients and control Japanese population. Spine 21: 469–473PubMedCrossRefGoogle Scholar
  14. 14.
    Ikata T, Takeuchi R, Takada K, Yamaoka K (1980) Epidemiologic study of ossification of the spinal ligaments (in Japanes). In: Investigation Committee 1979 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 9–16Google Scholar
  15. 15.
    Ohtani K, Higuchi M, Watanabe T, Nakai S, Fujimura S, Mitsuashi S, Kosaka M, Shibasaki T, Tsufuku M, Saitou T (1980) Epidemiological study of ossification of the posterior longitudinal ligaments in the cervical spine in Yaeyama (in Japanese). In: Investigation committee 1979 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 17–18Google Scholar
  16. 16.
    Ohtsuka K, Terayama K, Wada K, Kasuga K, Matsushima M, Machida T, Furukawa K (1984) Epidemiological study of ossification of the spinal ligaments in Yachiho, Nagano (in Japanese). In: Investigation committee 1983 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 63–67Google Scholar
  17. 17.
    Sakou T, Tomimura K, Maehara T, Kawamura H, Morizono Y, Nagamine T (1978) Epidemiological study of ossification of the posterior longitudinal ligaments in the cervical spine in Okinawa (in Japanese). In: Investigation committee 1977 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 172–173Google Scholar
  18. 18.
    Sakou T, Morimoto N (1982) Epidemiological study of ossification of the posterior longitudinal ligaments in the cervical spine in Kagoshima (in Japanese). In: Investigation committee 1981 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 20–24Google Scholar
  19. 19.
    Miura Y, Furusho T, Ibaraki K, Takemitu Y (1992) Genetic studies for OPLL: analysis of twin (in Japanese). In: Investigation committee 1991 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 5–7Google Scholar
  20. 20.
    Sugawara O, Takemitsu Y, Suematsu N, Atsuta Y (1991) HLA haplotype analysis of the family of patients with OPLL (in Japanese). In: Investigation committee 1990 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 10–12Google Scholar
  21. 21.
    Kimura T, Cheah KSE, Chan SDH, Lui VCH, Mattei MG, van der Rest M, Ono K, Solomon E, Ninomiya Y, Olsen BR (1989) The human a2 (XI) collagen (COL11A2) chain. J Biol Chem 264 (23): 13910–13916PubMedGoogle Scholar
  22. 22.
    Line S, Rhodes C, Yamada Y (1993) Molecular biology of cartilage matrix. In: Nöda M (ed) Cellular and molecular biology of bone, 1st ed. Academic, San Drego, pp 539–555Google Scholar
  23. 23.
    Arai K, Uehara K, Nagai Y (1989) Expression of type II and type XI collagens in canine mammary mixed tumors and demonstrations of collagen production by tumor cells in collagen gel culture. Jpn J Cancer Res 80: 840–847PubMedCrossRefGoogle Scholar
  24. 24.
    Yamazaki M, Goto S (1992) Expression of type XI collagen in ossification of posterior longitudinal ligament of the spine (OPLL) (in Japanese). In: Investigation committee Report on the ossification of the spinal ligament of the Japanese Ministry of Public Health and Welfare, pp 39–42Google Scholar
  25. 25.
    Yamazaki M, Moriya H, Goto S, Saitoh Y, Arai K, Nagai Y (1991) Increased type XI collagen expression in the spinal hyperostotic mouse ( TWY/TWY ). Calcif Tissue Int 48: 182–189CrossRefGoogle Scholar
  26. 26.
    Paralkar V, Wueeks B, Yu Y (1992) Recombinant human bone morphogenetic protein 2B stimulates PC20 cell differentiation: potentiation and binding to type IV collagen. J Cell Biol 119: 1724–1728CrossRefGoogle Scholar
  27. 27.
    Wang EA (1990) Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sei USA 87: 2220–2224CrossRefGoogle Scholar
  28. 28.
    Yaoi Y, Hashimoto K, Takahara K, Kato I (1991) Insulin binds to type V collagen with retention of mitogenic activity. Exp Cell Res 194: 180–185PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1997

Authors and Affiliations

  • Shunji Matsunaga
    • 1
  • Takashi Sakou
    • 1
  • Hiroshi Uehara
    • 1
  • Masao Yamaguchi
    • 1
  • Hiroaki Koga
    • 1
  • Kyouji Hayashi
    • 1
  1. 1.Department of Orthopaedic Surgery, Faculty of MedicineKagoshima UniversityKagoshima, 890Japan

Personalised recommendations