Changes in Hair: Causative Factors

  • Masumi Inaba
  • Yoshikata Inaba


Much can be learned about the hormonal control of hair growth by studying the sebaceous glands, since the responses of the various components of the pilosebaceous unit are probably similar or identical. Adachi and Kano (1970) have indicated that dihydrotestosterone (DHT) is the active form that testosterone takes in the hair follicle. They showed that glucose-6-phosphate-dehydrogenase (G6PDH), which is stimulated cyclic adenosine monophosphate (AMP), increases considerably during the anagen phase of hair growth (see Section There is a mutual correlation between the degree of progress of alopecia and falling androgen levels. In the skin, evidently, the peripheral metabolite of testosterone, 5α-DHT, and not testosterone itself is responsible for the stimulation of the matrix cells in the hair follicle, e.g., in women with hirsutism (Jenkins and Ash 1973). The same applies to the sebaceous gland in acne (Sansone-Bazzano and Reisner 1971).


Hair Follicle Hair Growth Sebaceous Gland Dermal Papilla Hair Bundle 
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Copyright information

© Springer Japan 1996

Authors and Affiliations

  • Masumi Inaba
    • 1
  • Yoshikata Inaba
    • 2
    • 3
  1. 1.Department of Aesthetic Plastic SurgeryInaba ClinicSuginami-ku, Tokyo, 166Japan
  2. 2.Department of DermatologyThe Jikei University School of MedicineMinato-ku, Tokyo, 105Japan
  3. 3.Department of DermatologyInaba Aesthetic Plastic SurgerySuginami-ku, Tokyo, 166Japan

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