Much can be learned about the hormonal control of hair growth by studying the sebaceous glands, since the responses of the various components of the pilosebaceous unit are probably similar or identical. Adachi and Kano (1970) have indicated that dihydrotestosterone (DHT) is the active form that testosterone takes in the hair follicle. They showed that glucose-6-phosphate-dehydrogenase (G6PDH), which is stimulated cyclic adenosine monophosphate (AMP), increases considerably during the anagen phase of hair growth (see Section 18.104.22.168). There is a mutual correlation between the degree of progress of alopecia and falling androgen levels. In the skin, evidently, the peripheral metabolite of testosterone, 5α-DHT, and not testosterone itself is responsible for the stimulation of the matrix cells in the hair follicle, e.g., in women with hirsutism (Jenkins and Ash 1973). The same applies to the sebaceous gland in acne (Sansone-Bazzano and Reisner 1971).
KeywordsHair Follicle Hair Growth Sebaceous Gland Dermal Papilla Hair Bundle
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