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Fundamental Aspects of Hyperthermia on Cellular and Molecular Levels

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Book cover Thermotherapy for Neoplasia, Inflammation, and Pain

Summary

Recent studies have demonstrated that apoptosis induction via the intracellular signaling cascade, consisting mainly of the p53 gene, plays an important role in cell death due to various cell injury factors. It has been reported that hsp72 protein is involved in thermotolerance induction, thereby at least partly regulating thermosensitivity. In this chapter, we review various aspects of hyperthermia, namely, thermosensitivity, sublethal thermal damage repair (SLTDR), cell phase response to heat, step-down and step-up heating, thermotolerance, apoptosis, heat shock protein (hsp), and p53 protein and its status at the cellular and molecular levels, and introduce articles concerning these published by our group.

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Author information

Authors and Affiliations

  1. Departments of Experimental Radiology, Fukui Medical University, Matsuoka, Fukui, 110-1193, Japan

    Sachiko Hayashi, Eiichi Kano, Masanori Hatashita & Hideki Matsumoto

  2. Departments of Otorhinolaryngology, Fukui Medical University, Matsuoka, Fukui, 110-1193, Japan

    Toshio Ohtsubo

  3. Departments of Surgery, Fukui Medical University, Matsuoka, Fukui, 110-1193, Japan

    Kanji Katayama

Authors
  1. Sachiko Hayashi
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  2. Eiichi Kano
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  3. Masanori Hatashita
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  4. Toshio Ohtsubo
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  5. Kanji Katayama
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  6. Hideki Matsumoto
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Editor information

Editors and Affiliations

  1. Department of Environmental Physiology, Institute of Tropical Medicine, Nagasaki University, 852-8523, Nagasaki, Japan

    Mitsuo Kosaka

  2. Health Research Foundation, 606-8225, Kyoto, Japan

    Tsutomu Sugahara

  3. Clinic of Rheumatology, Physical Medicine, and Balneology, University of Giessen, Bad Nauheim, Germany

    Klaus L. Schmidt

  4. Max Planck Institute for Physiological and Clinical Research, W.G. Kerckhoff Institute, Bad Nauheim, Germany

    Eckhart Simon

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© 2001 Springer Japan

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Hayashi, S., Kano, E., Hatashita, M., Ohtsubo, T., Katayama, K., Matsumoto, H. (2001). Fundamental Aspects of Hyperthermia on Cellular and Molecular Levels. In: Kosaka, M., Sugahara, T., Schmidt, K.L., Simon, E. (eds) Thermotherapy for Neoplasia, Inflammation, and Pain. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67035-3_38

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  • DOI: https://doi.org/10.1007/978-4-431-67035-3_38

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67037-7

  • Online ISBN: 978-4-431-67035-3

  • eBook Packages: Springer Book Archive

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