Skip to main content
SpringerLink
Log in

Photon Emission by Natural Radical Scavengers in the Presence of Active Oxygen Species

  • Conference paper
Food Factors for Cancer Prevention

Summary

The occurrence and intensity of photon emission were observed to be closely related to the partial structures of flavonoids. Photon emission P is suggested to be given by [P] = k [X] [Y] [Z]. The photon constants k of catechins and gallic acid in the presence of hydrogen peroxide as X and acetalde-hyde as Z were calculated from k 1 k 2, and k 3 of [P] = k 1 [X] [Y] f (z), [P] = k 2 [Y] [Z] f (x), and [P] = k 3 [X] [Z] f (y). k 1 showed greater differences depending on the structure of catechins than k 2 and k 3. The XYZ photon emission system is thought to consist of the transformation of energy. From the results of analysis by high-pressure liquid chromatography (HPLC) or antioxidative effects against lipid autoxidation, the XYZ system is suggested to be a scavenging mechanism of active oxygen species. DDMP (2,3-dihydro-2,5-dihydroxy-6-methyl-4H-pyran-4-one) saponin from soybean showed as strong an effect as Z in the presence of hydrogen peroxide and phenolic compounds. The XYZ system suggests that natural radical scavengers have various combinations for synergistic inhibition of the radical reactions.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kelvin JAD (1987) Protein damage and degradation by oxygen radicals. J Biol Chem 262:9895–9901

    Google Scholar 

  2. Annie A, Paolo U (1993) DNA nicking by ultraviolet radiation is enhanced in the presence of iron and of oxygen. Photochem Photobiol 57:508–512

    Article  Google Scholar 

  3. Bruce NA (1983) Carcinogens and anticarcinogens. Science 221:1256–1264

    Article  Google Scholar 

  4. Witz G (1982) Active oxygen species as factors in multistage carcinogenesis. Soc Exp Biol Med 198:675–682

    Article  Google Scholar 

  5. Palozza P, Agostara G, Piccioni E, Bartoli GM (1994) Different role of lipid peroxidation in oxidative stress-induced lethal injury in normal and tumor thymocytes. Arch Biochem Biophys 312: 88–94

    Article  PubMed  CAS  Google Scholar 

  6. Chedekel RM, Smith KS, Post WP, Pokora A, Vessell LD (1978) Photodestruction of phenomelanin: Role of oxygen. Proc Natl Acad Sci USA 75:5395–5399

    Article  PubMed  CAS  Google Scholar 

  7. Ames NB, Cathcart R, Schwiers E, Hochstein P (1981) Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: A hypothesis. Proc Natl Acad Sci USA 78:6858–6862

    Article  PubMed  CAS  Google Scholar 

  8. Nakayama T, Kuno T, Hiramitsu M, Osawa T, Kawakishi S (1993) Antioxidative and prooxidative activity of caffeic acid toward H2O2-induced DNA strand breakage dependent on the state of the Fe iron in the medium. Biosci Biotech Biochem 57:174–178

    Article  CAS  Google Scholar 

  9. Mora A, Paya M, Rios JL, Alcaraz MJ (1990) Structure-activity relationships of polymethoxyflavones and other Flavonoids as inhibitors of non-enzymatic lipid peroxidation. Biochem Pharmacol 40:793–797

    Article  PubMed  CAS  Google Scholar 

  10. Nakayama T, Yamada M, Osawa T, Kawakishi S (1993) Suppression of active oxygen-induced cytotoxicity by Flavonoids. Biochem Pharmacol 45:265–267

    Article  PubMed  CAS  Google Scholar 

  11. Robak J, Gryglewski JR (1988) Flavonoids are scavengers of superoxide anions. Biochem Pharmacol 37:837–841

    Article  PubMed  CAS  Google Scholar 

  12. Husain RS, Cillard J, Cillard P (1987) Hydroxyl radical scavenging activity of Flavonoids. Phytochemistry 26:2489–2491

    Article  CAS  Google Scholar 

  13. Sorata Y, Takahama V, Kimura M (1984) Protective effect of quercetin and rutin on photosensitized lysis of human erythrocytes in the presence of hematoporphyrin. Biochem Biophys Acta 799:313–317

    Article  PubMed  CAS  Google Scholar 

  14. Herrmann K (1976) Flavonols and flavones in food plants. J Fd Technol 11:433–448

    Article  CAS  Google Scholar 

  15. Yoshiki Y, Okubo K, Onuma M, Igarashi K (1995) Chemilumines-cence of benzoic and cinnamic acids, and Flavonoids in the presence of aldehyde and hydrogen peroxide or hydroxyl radical by Fenton reaction. Phytochemistry 39:225–229

    Article  CAS  Google Scholar 

  16. Yoshiki Y, Okubo K, Igarashi K (1995) Chemiluminescence of anthocyanins in the presence of acetaldehyde and ferf-butyl hydroperoxide. J Biolumin Chemilumin 10:335–338

    Article  PubMed  CAS  Google Scholar 

  17. Bors W, Heller W, Michel C, Saran M (1990) Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol 186:343–355

    Article  PubMed  CAS  Google Scholar 

  18. Puppo A (1992) Effect of Flavonoids on hydroxyl radical formation by Fenton-type reactions: Influence of the iron chelator. Phytochemistry 31:85–88

    Article  CAS  Google Scholar 

  19. Yoshiki Y, Kahara T, Igarashi K, Yotsuhashi K, Okubo K (1995) Chemiluminescence of oxygen radical scavengers such as DDMP saponins in the presence of radicals and aldehyde, 210th ACS National Meeting Aug. 20–24, abstract AGFD 183

    Google Scholar 

  20. Yoshiki Y, Kahara T, Okubo K, Igarashi K, Yotsuhashi K (1996) Chemiluminescence mechanism of catechins in the presence of active oxygen. J Biolumin Chemilumin 11:131–136

    Article  PubMed  CAS  Google Scholar 

  21. Jovanovic VS, Hara Y, Steenken S, Simic GM (1995) Antioxidant potential of gallocatechins: A pulse radiolysis and laser photolysis study. J Am Chem Soc 117:9881–9888

    Article  CAS  Google Scholar 

  22. Yoshiki Y, Kahara T, Igarashi K, Yotsuhashi K, Okubo K (1997) Chemiluminescence of catechins and gallic acid in the presence of acetaldehyde and active oxygen species, (in press)

    Google Scholar 

  23. Amarowicz R, Shimoyamada M, Okubo K (1994) Hypocho-lesterolemic effects of saponins. Roczn Pzh 45:125–131

    CAS  Google Scholar 

  24. Ohminami H, Kimura Y, Okuda H, Arichi S, Yoshikawa M, Kitagawa I (1984) Effects of soyasaponins on liver injury induced by highly peroxidized fat in rat. Planta Med 46:440–441

    Article  Google Scholar 

  25. Okubo K, Kudou S, Uchida T, Yoshiki Y, Yoshikoshi M, Tonomura M (1994) Soybean saponin and isoflavonoids: structure and antiviral activity for cancer prevention against human immunodeficiency virus in vitro. Food phytochemicals for cancer prevention I. ACS Symposium 546:330–339

    Article  CAS  Google Scholar 

  26. Yoshiki Y, Okubo K (1995) Active oxygen scavenging activity of DDMP saponin. Biosci Biotech Biochem 59:1556–1557

    Article  CAS  Google Scholar 

  27. Yoshiki Y, Kudo K, Yoshikoshi M, Okubo K (1995) Chemiluminescence of soybean saponins in the presence of active oxygen species and scavenger in soybean fermented foods, International Chemical Congress of Pacific Basin Societies, Honolulu, Dec. 17–22, abstract, AGRO 1607

    Google Scholar 

  28. Yoshiki Y, Kinumi M, Kahara T, Okubo K (1996) Chemiluminescence of soybean saponins in the presence of active oxygen species. Plant Sci 116:125–129

    Article  CAS  Google Scholar 

  29. Nakatani N, Kikuzaki H (1987) A new antioxidative glucoside isolated from Oregano (Origanum vulgate L.). Agric Biol Chem 51:2727–2732

    Article  CAS  Google Scholar 

  30. Niki E, Saito T, Kawakami A, Kamiya Y (1983) Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C. J Biol Chem 259:4177–4182

    Google Scholar 

  31. Mori A, Wang X, Liu J (1994) Electron spin resonance assay of ascorbate free radicals in vivo. Methods Enzymol 233:149–154

    Article  PubMed  CAS  Google Scholar 

  32. Kagan EV, Packer L (1994) Light-induced generation of vitamin E radicals assessing vitamin E regeneration. Methods Enzymol 234:316–320

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, 1-1 Tsutsumitori, Amamiyamachi, Aoba-ku, Sendai, Miyagi 981, Japan

    Yumiko Yoshiki & Kazuyoshi Okubo

  2. Department of Bioproduction, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997, Japan

    Kiharu Igarashi

Authors
  1. Yumiko Yoshiki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazuyoshi Okubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kiharu Igarashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Food Science and Technology Faculty of Agriculture, Kyoto University, Oiwake-cho, Kitashirakawa, Kakyo-ku, Kyoto, 606-01, Japan

    Hajime Ohigashi Ph.D. (Professor) (Professor)

  2. Department of Applied Biological Sciences Faculty of Agriculture, Nagoya University, Furocho, Chikusa-ku, Nagoya, Aichi, 464-01, Japan

    Toshihiko Osawa Ph.D. (Professor) (Professor)

  3. Lipid Science Laboratory, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, 2-1-2 Kannondai, Tsukuba, Ibaraki 305, Japan

    Junji Terao Ph.D. (Head) (Head)

  4. Nutrition and Epidemiology, Department of Agriculture, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156, Japan

    Shaw Watanabe M.D. (Professor) (Professor)

  5. First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602, Japan

    Toshikazu Yoshikawa M.D. (Associate Professor) (Associate Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Japan

About this paper

Cite this paper

Yoshiki, Y., Okubo, K., Igarashi, K. (1997). Photon Emission by Natural Radical Scavengers in the Presence of Active Oxygen Species. In: Ohigashi, H., Osawa, T., Terao, J., Watanabe, S., Yoshikawa, T. (eds) Food Factors for Cancer Prevention. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67017-9_62

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-67017-9_62

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67019-3

  • Online ISBN: 978-4-431-67017-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation