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Cellular Adaptation in Hibernating Myocardium in the Human

  • Chapter
Cardiac Adaptation and Failure

Summary

The aim of this study was to investigate morphologic changes in chronic hibernation. Light and electron microscopy were performed on myocardium derived from the anterior wall of the left ventricle of 165 patients during coronary artery bypass grafting. The changes seen in a substantial part of the cardiomyocytes corresponded to “dedifferentiation” rather than atrophic “degeneration”. The affected cardiomyocytes showed a partial to complete loss of sarcomeres, sarcoplasmic reticulum, and T-tubules and presented an abundant amount of glycogen, and lots of small mitochondria. The volume of the cells was similar to that of normal cells. The number of the affected cells was consistently higher in endocardial parts than in epicardial ones. The cell changes occurred in the myocardium of patients both with and without a previous infarction. A significant relationship was found in noninfarcted patients between the presence of affected cells and the amount of connective tissue. It is proposed that myocardial segments in which these structural changes prevail will not recover immediately after revascularization but that they might show a delayed recovery of function, because structural remodeling requires time in order to regain sufficient contractile material and to normalize the amount of connective tissue between the cardiomyocytes.

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Author information

Authors and Affiliations

  1. Department of Molecular Cell Biology and Genetics, Cardiovascular Research Institute, Maastricht, University of Limburg, P.O. Box 616, 6200 MD, Maastricht, The Netherlands

    J. Ausma, F. Ramaekers & M. Borgers

  2. Department of Cardiac Surgery, Katholieke Universiteit Leuven, Gashvisberg, Heerestraat, Belgium

    B. Shivalkar & W. Flameng

  3. Department of Life Sciences, Janssen Research Foundation, Turnhoutseweg 30, 2340, Beerse, Belgium

    F. Thone & M. Borgers

Authors
  1. J. Ausma
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  2. F. Ramaekers
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  3. B. Shivalkar
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  4. F. Thone
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  5. W. Flameng
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  6. M. Borgers
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Editor information

Editors and Affiliations

  1. Division of Cardiology, The First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565, Japan

    Masatsugu Hori M.D., Ph.D. (Chief) (Chief)

  2. The First Department of Internal Medicine, Fukushima Medical College, 1 Hikarigaoka, Fukushima, 960-12, Japan

    Yukio Maruyama M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  3. Department of Physiology, University of Limburg, P.O. Box 616, 6200 MD, Maastricht, The Netherlands

    Robert S. Reneman M.D., Ph.D. (Professor of Physiology/Scientific Director CARIM) (Professor of Physiology/Scientific Director CARIM)

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© 1994 Springer Japan

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Ausma, J., Ramaekers, F., Shivalkar, B., Thone, F., Flameng, W., Borgers, M. (1994). Cellular Adaptation in Hibernating Myocardium in the Human. In: Hori, M., Maruyama, Y., Reneman, R.S. (eds) Cardiac Adaptation and Failure. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67014-8_7

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  • DOI: https://doi.org/10.1007/978-4-431-67014-8_7

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67016-2

  • Online ISBN: 978-4-431-67014-8

  • eBook Packages: Springer Book Archive

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