Summary
The hypertrophied heart typically exhibits various changes in architecture as well as in histology, according to the cause and stage of hypertrophy. The macroscopic and histologic changes in hypertrophied hearts are briefly described. The various dimensions of the autopsied hearts, width of myocytes, contents of myocytes, and extent of fibrosis were compared between one group of patients who seemed to have hypertrophied hearts secondary to arterial hypertension in adaptive growth or a prolonged state of successful adaptation, and a second group of patients who appeared to have almost normal hearts. There were significant differences in heart weight, the length of the inflow portion of the left ventricle, the wall thickness of the left ventricle and interventricular septum, the width of myocytes, and the extent of fibrosis.
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References
Messerli FH (1983) Clinical determinants and consequences of left ventricular hypertrophy. Am J Med 75:51–56
Grant RP (1953) Architectonics of the heart. Am Heart J 46:405–431
Hutchins GM, Bulkley BH, Moore GW, Piasio MA, Lohr FT (1978) Shape of the human cardiac ventricles. Am J Cardiol 41:646–654
Ferrans VJ (1984) Cardiac hypertrophy: morphological aspect. In: Zak R (ed) Growth of the heart in health and disease. Raven, New York, pp 187–239
Linzbach AJ (1960) Heart failure from the point of view of quantitative anatomy. Am J Cardiol 5:370–382
Hangartner JRW, Marley NJ, Whitehead A, Thomas AC, Davis MJ (1985) The assessment of cardiac hypertrophy at autopsy. Histopathology 9:1295–1306
Zeek PM (1942) Heart weight. 1. The weight of the normal human heart. Arch Pathol 34:820–832
Silver MM (1983) Gross examination and structure of the heart. In: Silver MD (ed) Cardiovascular pathology, vol 1. Churchill Livingstone, pp 1-30
Roberts WC, Ferrans VJ (1975) Pathologic anatomy of the cardiomyopathies. Idiopathic dilated and hypertrophic types, infiltrative types, and endomyocardial disease with and without eosinophilia. Hum Pathol 6:287–342
Eckner FAO, Brown BW, Davidson DL, Glagov S (1969) Dimensions of normal human hearts. After standard fixation by controlled pressure coronary perfusion. Arch Pathol 88:497–507
Krovetz LJ (1975) Age-related changes in size of the aortic valve annulus in man. Am Heart J 90:569–574
Silver MA, Roberts WC (1985) Detailed anatomy of the normally functioning aortic valve in hearts of normal and increase weight. Am J Cardiol 55:454–461
Edwards WD (1987) Applied anatomy of the heart. In: Brandenburg RO, Fuster V, Giuliani ER, McGoon DC (eds) Cardiology. Fundamentals and practice. Year Book Publishers, Chicago, London, pp 47–112
Richter GW, Kellner A (1963) Hypertrophy of the human heart at the level of fine structure. An analysis and two postulates. J Cell Biol 18:195–206
Marron BJ, Ferrans VJ, Roberts WC (1975) Ultrastructural features of degenerated cardiac muscle in patients with cardiac hypertrophy. Am J Pathol 79:387–434
Fuster V, Danielson MA, Rob RA, Broadbent JC, Brown AL Jr, Elveback R (1977) Quantitation of left ventricular myocardial fiber hypertrophy and interstitial tissue in human hearts chronically increased volume and pressure overload. Circulation 55:504–508
Schaper J (1983) Hypertrophy in the human heart: evaluation by qualitative and quantitative light and electron microscopy. In: Alpert NR (ed) Perspective in cardiovascular research, vol 7, Myocardial hypertrophy and failure. Raven, New York, pp 177–196
Tanaka M, Fujiwara H, Onodera T, Wu DJ, Matsuda M, Hamashima Y, Kawai C (1987) Quantitative analysis of narrowing of intramyocardial small arteries in normal hearts, hypertensive hearts, and hearts with hypertrophic cardiomyopathy. Circulation 75:1130–1139
Schwartzkopff B, Frenzel H, Dieckerhoff J, Betz P, Flasshove M, Schulte HD, Mundhenke M, Motz W, Strauer BE (1992) Morphometric investigation of human myocardium in arterial hypertension and valvular aortic stenosis. Eur Heart J 13[Suppl D]:17–23
Schwarz F, Flameng W, Schaper J, Hehrlein F (1979) Correlation between myocardial structure and diastolic properties of the heart in chronic aortic valve disease: effects of corrective surgery. Am J Cardiol 42:895–903
Krayenbuehl HP, Hess OM, Monrad ES, Schneider J, Mall G, Turina M (1989) Left ventricular myocardial structure in aortic valve disease before, intermediate, and late after aortic valve replacement. Circulation 79:744–755
Schaper J, Schaper W (1983) Ultrastructural correlates of reduced cardiac function in human heart disease. Eur Heart J 4[Suppl A]:35–42
Ferreira R, Milei J, Forcada P, Beigelman R, Molteni L, Cutrin JC (1992) The hypertrophied myocardium and coronary disease. Structural changes in patients submitted to aortocoronary bypass surgery. Int J Cardiol 36:203–212
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© 1994 Springer Japan
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Imakita, M., Yutani, C. (1994). Morphology of Left Ventricular Hypertrophy in the Human. In: Hori, M., Maruyama, Y., Reneman, R.S. (eds) Cardiac Adaptation and Failure. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67014-8_18
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DOI: https://doi.org/10.1007/978-4-431-67014-8_18
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-67016-2
Online ISBN: 978-4-431-67014-8
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