Follicular Dendritic Cells

  • Morikazu Onji


Follicular dendritic cells (FDCs) take their name from the presence of dendritic processes on these cells. However, FDCs are a completely different type of cell from the dendritic cells (DCs) that are the subject of most of the chapters in this book. The ontogeny of FDCs is different from that of antigen-presenting DCs. DCs are known to originate in the bone marrow, and progenitors and precursors of DCs are known, but the origin of FDCs is unknown. DCs are widely distributed throughout the entire body, but FDCs exhibit a highly specialized type of distribution. They are localized in the light zones of the germinal centers in the secondary lymphoid follicles. The functions of FDCs have to do with B cells; especially, they stimulate the memory B cells. However, the main function of antigen-presenting DCs is to present antigens to T cells, although DCs are capable of performing a variety of functions as part of both the innate and adaptive immune responses.


Primary Biliary Cirrhosis Germinal Center Lymphoid Follicle Follicular Dendritic Cell High Endothelial Venule 
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Recommended Readings

  1. Burton GF, Keele BF, Estes, et al. (2002) Follicular dendritic cell contributions to HIV pathogenesis. Semin Immunol 14:275–284PubMedCrossRefGoogle Scholar
  2. Grouard G, Durand I, Filgueira L, et al. (1996) Dendritic cells capable of stimulating T cells in germinal centres. Nature 384:364–367PubMedCrossRefGoogle Scholar
  3. Tew JG, Wu J, Fakher M, et al. (2001) Follicular dendritic cells: beyond the necessity of T cell help. Trends Immunol 22:361–367PubMedCrossRefGoogle Scholar

Copyright information

© Morikazu Onji 2004

Authors and Affiliations

  • Morikazu Onji
    • 1
  1. 1.Third Department of Internal MedicineEhime University School of MedicineOnsen-gun, EhimeJapan

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