Through the evolutionary process, two distinct and highly sophisticated defense mechanisms have developed in human beings for survival in hostile environments. One is the innate immune system, which reacts rapidly (from within minutes to a few hours) and in a rather simple way attacks pathogens. The other, the acquired immune system, has evolved to provide a more adaptive and highly specific defense response to agents, antigens (Ags), and other substances that are nonself and dangerous to the host. This adaptive immune system also possesses the unique ability to induce tolerance to self-structures and possibly to nondangerous stimuli. It is important to understand how this balance between immune response and immune tolerance is regulated in vivo. In order to maintain homeostasis in the body, cells of the effector and regulatory limbs of the immune system interact in a coordinated way so that the magnitude and nature of the effector immune response is purposeful and functional in the context of a particular stimulus.
KeywordsDendritic Cell Atopic Dermatitis Atopic Dermatitis Patient Human Allergy Mucosal Milieu
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