History and Concept of Dendritic Cells

  • Morikazu Onji


In 1868, medical student Paul Langerhans discovered a population of dendritically shaped cells in the suprabasal region of the epidermis. These cells now bear his name. The reactivity of these cells to gold salt made him believe that they represented sensory nerve endings. However, today we know that Langerhans cells (LCs) are dendritic leukocytes, which perform a variety of activities; in particular, they function as professional antigen-presenting cells (APCs).


Dendritic Cell Sensory Nerve Ending Dendritic Cell Precursor Defective Functioning Dendritic Cell Producer 
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Recommended Readings

  1. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:245–252PubMedCrossRefGoogle Scholar
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Copyright information

© Morikazu Onji 2004

Authors and Affiliations

  • Morikazu Onji
    • 1
  1. 1.Third Department of Internal MedicineEhime University School of MedicineOnsen-gun, EhimeJapan

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