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Clinical Applications

  • Keiko Esaki
  • Philip T. Chapman

Abstract

A large number of mouse monoclonal antibodies have been applied to cancer, infectious diseases and thrombosis for therapeutic purposes. However, their therapeuticeutic effects in human patients are limited, due to their high immunogenicity in humanp atients. To eliminate this immunogenicity, the humanization of mouse antibodies has been established using genetic engineering technology.

Keywords

Sensor Chip Dissociation Rate Constant Chimeric Antibody Association Rate Constant Hepes Buffer Saline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2000

Authors and Affiliations

  • Keiko Esaki
    • 1
  • Philip T. Chapman
    • 2
  1. 1.Pharmaceutical Technology Lab.Chugai Pharmaceutical Co., Ltd.GotembaJapan
  2. 2.Ciphergen Biosystems Ltd.Camberley, SuureyUK

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