Regulatory Mechanisms of Thrombomodulin Expression in the Human Umbilical Vein Endothelial Cells
Thrombomodulin (TM) is a cell surface glycoprotein that plays an important role in inhibition of intravascular coagulation as a cofactor for the thrombin-catalyzed activation of protein C.1 It contributes to thromboresistant properties of endothelium. We reported that TM-fragments increased in plasma of patients with various thrombotic disorders such as DIC, ARDS and pulmonary thromboembolism.2 However, it is not clear whether the increase of TM-fragments in plasma is caused simply by vascular damages or reflects an increase of expression of TM in endothelial cells. In this paper, we summarize our studies on the regulatory mechanisms of TM expression in vitro assuming its role in pathogenesis of hypercoagulable states.
KeywordsHuman Umbilical Vein Endothelial Cell Phorbol Myristate Acetate Phorbol Myristate Acetate Cesium Chloride Thrombotic Disorder
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Ohdama S. and Aoki N. in preparation.Google Scholar