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Significance of Plasminogen Activators and Plasminogen Activator Inhibitors in Human Lung Cancer

  • M. Nagayama
  • H. Hayakawa
  • A. Sato
  • T. Urano
  • Y. Takada
  • A. Takada
Conference paper

Abstract

Plasminogen activators (PAs) are serine proteases which convert plasminogen to plasmin and play a major role to regulate intravascular fibrinolysis and extracellular proteolysis.1 At least two types of plasminogen activator, tissue plasminogen activator (t-PA), urokinase (UK), have been identified. UK and its precursor, pro-UK, which are released from cancer cells and bind to specific cell surface receptor of these cells,2–3is considered to play important roles in tumor invasion or metastsis by regulating the degradation of the extracelluler matrix.

Keywords

Cancer Tissue Plasminogen Activator Maximal Diameter Plasminogen Activator Inhibitor Human Lung Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1992

Authors and Affiliations

  • M. Nagayama
    • 1
  • H. Hayakawa
    • 1
  • A. Sato
    • 1
  • T. Urano
    • 2
  • Y. Takada
    • 2
  • A. Takada
    • 2
  1. 1.Second Department of Internal MedicineHamamatsu University, School of MedicineHamamatsu-shi, Shizuoka-kenJapan
  2. 2.Second Department of PhysiologyHamamatsu University, School of MedicineHamamatsu-shi, Shizuoka-kenJapan

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