Abstract
The luminal surface of blood vessels is covered with endothelium which possesses various antithrombogenic functions and maintain blood fluidity. The anti-thrombogenic functions include the production of PGI2, the secretion of tissue plasminogen activator, and the production of heparin-like proteoglycans and thrombomodulin(TM)(1). PGI2 inhibits platelet functions and causes blood vessel dilatation(2). Tissue plasminogen activator activates plasminogen to plasmin. Heparin-like proteoglycans activate antithrombin III from a progressive inhibitor to an immediate-type inhibitor, which inhibits activated factor Xa and thrombin(3). TM is an endothelial associated glycoprotein that convert thrombin from a procoagulant protease to an anticoagulante 4, 5).
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© 1992 Springer Japan
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Maruyama, I., Akashi, M., Okadome, T. (1992). Antithrombogenic Biomaterials. Poly(Vinyl Chloride) with Heparin-and/or PGI2-Immobilized in Hydrogels and Thrombomodulin-Immobilized Beads.. In: Takada, A., Budzynski, A.Z. (eds) Hemostasis and Circulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66925-8_29
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DOI: https://doi.org/10.1007/978-4-431-66925-8_29
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