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Haloperidol Kinetics in Senile Dementia

  • M. Nishimoto
  • T. Itaya
  • Ko. Ohara
  • K. Miyasato
  • Ke. Ohara
Conference paper

Abstract

The number of patients with dementie disease has increased and psychotic symptoms and behavioral disturbances with dementia are also observed.1 In these cases, antipsychotic drugs such as haloperidol has been widely used, the dosage generally based on a doctor’s clinical experience. Particularly in aged patients, individual deviation in pharmacokinetics becomes large and therapeutic dosage may often induce side effects such as the extrapyramidal syndrome. Thus, in the aged, it is especially important to establish an administration scheme on the basis of pharmacokinetic findings. Haloperidol is the most commonly prescribed antipsychotic drugs. Plasma concentration has been examined for all of the antipsychotic drugs, but haloperidol is considered the ideal agent for such studies because of the drug’s relatively simple metabolic pathway.2 Although, there have been many reports on the plasma concentration and clinical effects of haloperidol, those on effective plasma levels in aged patients are few. In the present study, we compared the plasma levels of haloperidol in the démentie patients above the age of 65 years who were given haloperidol due to psychotic symptoms such as delirium, hallucination, delusion and behavioral disturbances with those in schizophrenic patients under the age of 65.

Keywords

Antipsychotic Drug Psychotic Symptom Behavioral Symptom Behavioral Disturbance Senile Dementia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1992

Authors and Affiliations

  • M. Nishimoto
    • 1
  • T. Itaya
    • 1
  • Ko. Ohara
    • 1
  • K. Miyasato
    • 1
  • Ke. Ohara
    • 1
  1. 1.Department of Psychiatry and NeurologyHamamatsu University School of MedicineHamamatsuJapan

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