Peripheral Serotonergic Mechanisms in Health and Disease

  • M. H. Pietraszek
  • Y. Takada
  • A. Takada
Conference paper


Serotonin (5-hydroxytryptamine; 5HT) is found in the central nervous system, which contains serotonergic neurons, enterochromaffin cells in the intestine and platelets.1–3 Receptors for serotonin have been found in various tissues including the central nervous system, gastrointestinal tract , blood vessels, blood platelets and autonomic nerve endings.4 5-hydroxytryptamine is believed to play a role in physiology and pathophysiology of mammals. One of its most likely physiological roles is to aid in haemostasis by promoting platelet aggregation and by causing local vasoconstriction.2,3 It also has p a role in some forms of vascular disease and may contribute to vasospasm of cerebral or coronary arteries, especially with endothelial disfunction or damage5 Some evidence has implicated serotonin in the pathogenesis of migraine, peripheral vascular disease, coronary and cerebral vasospasm or essential p p p hypertension. On the other hand, clinical studies have provided evidence that serotonin in the brain is implicated in the state of depression. 6,7 Many authors consider that blood platelets share a number of properties with serotonergic neurons because of their specific biochemical mechanisms for uptake and storage of amine. 8,9 Thus, the study of blood serotonin would provide an useful model for certain aspects of neuronal physiology. The present study investigates blood serotonergic mechanisms in diseases with blood vessels disfunction like Thromboangiitis obliterans (Buerger’s disease), g Raynaud’s phenomenon, hypertension and diabetes mellitus as well as in mental disorders as depression and neurosis.


Peripheral Vascular Disease Cerebral Vasospasm Blood Platelet Serotonergic Neuron Serotonin Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Da Prada M., Richards J.G. and Kettler R. (1981) Platelets in Biology and Pathology. Amsterdam: Elsevier: 107–45.Google Scholar
  2. 2.
    Cohen R.A. and Vanhoutte P.M. (1985) Serotonin and the Cardiovascular System. New York: Raven Press : 105–12.Google Scholar
  3. 3.
    Van Zwieten P.A. (1987) Pathophysiological relevance of serotonin. J. Cardiovasc. Pharmacol. 10 (Suppl.3):S 19-S25.Google Scholar
  4. 4.
    Peroutka S.J. (1988) 5-hydroxytryptamine receptor subtypes. Ann. Rev. Neurosci. 11: 45–60.PubMedCrossRefGoogle Scholar
  5. 5.
    Vanhoutte P.M. (1985) Serotonin and the cardiovascular system. New York: Raven Press :123–33.Google Scholar
  6. 6.
    Cowen P.J. (1988) Recent views on the role of 5-hydroxytryptamine in depression. Curr. Opin. Psychiatry 3: 56–59.CrossRefGoogle Scholar
  7. 7.
    Coppen A.J. and Doogan D.P. (1988) Serotonin and its place in the pathogenesis of depression. J. Clin. Psychiatry 8 (suppl) : 4–11.Google Scholar
  8. 8.
    Pletscher A. (1988) Platelets as models : use and limitations. Experientia 44: 152–155.PubMedCrossRefGoogle Scholar
  9. 9.
    Stahl S.M. (1978) The human platelet- A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Arch. Gen. Psychiatry 34: 509–516.CrossRefGoogle Scholar
  10. 10.
    Anderson G.M., Young J.G., Ohen D.J., Schlicht K.R. and Patel N. (1981) Liquid-chromatografic determination of serotonin and tryptophan in whole blood and plasma. Clin. Chem. 5: 775–6.Google Scholar
  11. 11.
    Lingjaerde O. (1979) Inhibitory effect of ethanol on 5-hydroxytryptamine (serotonin) uptake in human blood platelets in vitro. Acta. Pharmacol.Toxicol. 45: 394–8.CrossRefGoogle Scholar
  12. 12.
    Pletscher A. (1987) The 5-hydroxytryptamine system of blood platelets : physiology and pathophysiology. Int. J. Cardiol. 14: 177–188.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1992

Authors and Affiliations

  • M. H. Pietraszek
    • 1
  • Y. Takada
    • 1
  • A. Takada
    • 1
  1. 1.Department of PhysiologyHamamatsu University School of MedicineHanda-cho, 431-31Japan

Personalised recommendations