Oxygen Free Radicals Inhibit Ca2+-pump Activity by Oxidizing Sulfhydryl Groups in Rat Heart Sarcolemmal Membrane
Although oxygen free radicals have been implicated as mediators of cellular injury in some pathophysiological conditions like myocardial ischemia-reperfusion , the mechanisms of myocardial cell damage caused by oxygen free radicals are still unclear. In this regard, it should be pointed out that oxygen free radicals are known to attack molecules of major biological significance and these include phospholipids, protein, and nucleic acids . Since sulfhydryl groups (SH groups) are known to regulate the membrane-bound enzyme activities in the cell [3, 4, 5, 6, 7], it is possible that the oxidation of SH groups in the membrane may lead to the depression of enzyme activities because of oxygen free radicals .
KeywordsATPase Activity Xanthine Oxidase Oxygen Free Radical Sulfhydryl Group Pump Activity
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- 5.Schuurman-stekhoven FMAH, Bonting SL (1981) Physiol Rev 61:1–76Google Scholar
- 9.Halliwell B, Gutteridge JM (1982) Advances in studies on heart metabolism. Bologna, CLUEB, pp 403–411.Google Scholar
- 11.Kaneko M, Elimban V, Dhalla NS (1989) Am J Physiol 257 (Heart Circ Physiol 26):H804–H811Google Scholar