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Hemostasis and Circulation pp 94–99Cite as

Altered Platelet Responses to Thromboxane A2 in Patients with Myelo-Proliferative Disorders

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Abstract

Thromboxane A2 (TXA2), a major arachidonic acid (AA) metabolite in platelets, is a potent stimulator of platelet functions and constrictor of vascular and respiratory smooth muscles [1,2]. Because of such potent biological activities and its formation in response to various stimuli, TXA2 has been implicated as a mediator in many pathophysiological conditions including myocardial infarction, stroke and anaphylaxis [2,3]. Furthermore, platelet dysfunctions due to defective TXA2 synthesis or subnormal responses to TXA2 are associated with bleeding tendency [4].

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Author information

Authors and Affiliations

  1. The First Division, Department of Internal Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

    Minoru Okuma, Takafumi Ishibashi, Kenjiro Tomo & Hiroshi Takayama

  2. Department of Pharmacology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan

    Fumitaka Ushikubi & Shu Narumiya

Authors
  1. Minoru Okuma
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  2. Fumitaka Ushikubi
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  3. Takafumi Ishibashi
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  4. Shu Narumiya
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  5. Kenjiro Tomo
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  6. Hiroshi Takayama
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Editor information

Editors and Affiliations

  1. Department of Physiology, Hamamatsu University, School of Medicine, 431-31, Hamamatsu, Shizuoka, Japan

    A. Takada

  2. Department of Biochemistry, Temple University, School of Medicine, Philadelphia, USA

    A. Z. Budzynski

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© 1992 Springer Japan

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Cite this paper

Okuma, M., Ushikubi, F., Ishibashi, T., Narumiya, S., Tomo, K., Takayama, H. (1992). Altered Platelet Responses to Thromboxane A2 in Patients with Myelo-Proliferative Disorders. In: Takada, A., Budzynski, A.Z. (eds) Hemostasis and Circulation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66925-8_17

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  • DOI: https://doi.org/10.1007/978-4-431-66925-8_17

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-70096-8

  • Online ISBN: 978-4-431-66925-8

  • eBook Packages: Springer Book Archive

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