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Molecular Mechanism of Shear Stress-Induced Platelet Aggregation

  • Y. Ikeda
  • M. Handa
  • Y. Kawai
  • K. Watanabe
Conference paper

Abstract

Blood circulating in vessels is exposed to shear stress caused by the force necessary to produce flow; the difference in velocity between layers situated at varying distances from the vessel wall determines the shear rate, which is directly proportional to the shear force and inversely proportional to the viscosity of blood. Previous studies have demonstrated that exposure of platelets to shear stress leads to aggregation in the absence of exogenous agonists (1) (2). Under high shear stress, which may mimic the rheological situation existing in certain districts of the arterial circulation, von Willebrand factor (vWf) may have a crucial role in the formation of the irreversible platelet aggregates (3) (4) . However, the precise molecular mechanism of shear stress-induced platelet aggregation (SIPA) has yet to be clarified.

Keywords

Shear Stress Platelet Aggregation High Shear Stress Precise Molecular Mechanism Vary Shear Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Hung, T.C., Hochmuth, R.M., Joist, J.H. and Stera, S.P. (1976) Trans. Am. Soc. Artif. Intern. Organs 22: 285–291.Google Scholar
  2. 2.
    Ikeda, Y., Murata, M., Araki, Y., Watanabe, K., Ando, Y., Itagaki, I., Mori, Y., Ichitani, M. and Sakai, K. (1988) Thromb. Res. 51: 157–163.PubMedCrossRefGoogle Scholar
  3. 3.
    Peterson, D.M., Stathopoulos, N.A., Giorgio, T.D., Hellums, J.D. and Moake, J.L. (1987) Blood 69: 625–628.PubMedGoogle Scholar
  4. 4.
    Moake, J. L., Turner, N.A., Stathopoulos, N.A., Nolasco, L., Hellums, J.D. (1988) Blood 71: 1366–1374.PubMedGoogle Scholar
  5. 5.
    Fukuyama, M., Sakai, K., Murata, M., Kawai, Y., Watanabe, K., Handa, M and Ikeda, Y. (1989) Thromb . Res . 54: 253–260.PubMedCrossRefGoogle Scholar
  6. 6.
    Ikeda, Y., Handa, M., Kawai, Y., Watanabe, K. and Ruggeri, Z.M. (1991) J. Clin. Invest. 87: 1234–1240.PubMedCrossRefGoogle Scholar
  7. 7.
    Weiss, H. J., Turitto, V.T. and Baumgartner, H.R . (1978) J. Lab. Clin. Med. 92: 750–764.PubMedGoogle Scholar
  8. 8.
    Back, C.H., Radbill, J.R. and Crawford A. (1977) J. Biomech. 10: 339–353.PubMedCrossRefGoogle Scholar
  9. 9.
    Lipowski, U.H ., Usami, S. and Chien, S. (1980) Microvasc. Res. 19: 297–319.CrossRefGoogle Scholar

Copyright information

© Springer Japan 1992

Authors and Affiliations

  • Y. Ikeda
    • 1
  • M. Handa
    • 1
  • Y. Kawai
    • 1
  • K. Watanabe
    • 1
  1. 1.Department of Hematology and Laboratory Medicine , School of MedicineKeio UniversityShinjuku-ku TokyoJapan, 160

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