Summary
It is observed that the prevalence of myopia is increasing in Japan and Asia. The objective of this stuky was to clarify the developmental mechanism of low myopia and to study the possibility of its treatment with drug. 1) Refractive changes of subject who engaged in VDT work for 2 years were studied. 2) Using an optometer (Nidek 2200), accommodative hysteresis was measured 8 minutes after looking at the near point. 3) Effect of endothelin-1 (ET-1) and nitric oxide (NO) on the bovine ciliary muscle was examined by in vitro study. 1) Late-onset and adult-onset myopia were observed. 2) Duration of accommodative hysteresis was longer in adult-onset myopia than with late-onset myopia, early onset myopia or emmetropia. 3) Contraction of the ciliary muscle found to be mediated by ET-1. The NO donor is closely related to the relaxation of the ciliary muscle contracted with ET-1. ET-1 is one cause of low myopia Some endothelin antagonists and NO donors may be useful for treating low myopia.
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© 2000 Springer Japan
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Tokoro, T. (2000). Developmental Mechanism of Low Myopia and Its Treatment. In: Lin, L.LK., Shih, YF., Hung, P.T. (eds) Myopia Updates II. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66917-3_18
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DOI: https://doi.org/10.1007/978-4-431-66917-3_18
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-70275-7
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