Advertisement

The Roles of the Equilibrium Dissociation Constant and the Receptor Concentration on the Time Course of Neuromuscular Block

  • Vladimir Nigrovic
  • Ashraf Banoub
  • Frank G. Standaert
Conference paper

Abstract

The equilibrium dissociation constants of various nondepolarizing muscle relaxants (MRs) with the postsynaptic nicotinic receptors at the end plates were previously postulated to influence the onset of neuromuscular block (NMB). The hypothesis was not rigorously tested. The goal of the present study was to analyze the course of NMB over time assuming different values for (i) the rate constants for interaction of MRs with the postsynaptic nicotinic receptors (the association, kassoc, and dissociation, kdossoc, rate constants) and (ii) the receptor concentration ([R]).

Keywords

Neuromuscular Block Receptor Occupancy Synaptic Cleft Equilibrium Dissociation Receptor Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Nigrovic V, Banoub M: Anesth Analg 76: 85–91, 1993.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Vladimir Nigrovic
    • 1
  • Ashraf Banoub
    • 1
  • Frank G. Standaert
    • 1
  1. 1.Departments of Anesthesiology and PharmacologyMedical College of OhioToledoUSA

Personalised recommendations