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Comparison of the Neuromuscular and Circulatory Effects of SZ1676, SZ1677 and Rocuronium in Cats

  • E. Sylvester Vizi
  • Margit Doda
  • Hideo Nagashima
  • Francis F. Foldes
Conference paper

Abstract

Searching for muscle relaxants (MR) with rapid onset and short duration of action, which are free of cardiovascular side effects, close to 100 steroid MR were synthesized and screened for neuromuscular (NM) activity. Two of these, SZ1676, 1-[3α,17β-bis(acetyloxy)-2β-(1;4-dioxa-8-azaspiro[4,5]dec-8-yl)-5α-androstan-16β-yl]-1-(2propenyl)-pyrrolidinium Br. and its 3-OH derivative SZ1677, were selected for further studies.

Keywords

Sciatic Nerve Muscle Relaxant Vagus Stimulation Tibialis Anterior Muscle Control Heart Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • E. Sylvester Vizi
    • 1
  • Margit Doda
    • 1
  • Hideo Nagashima
    • 2
  • Francis F. Foldes
    • 2
  1. 1.Department of Pharmacology, Institute of Experimental MedicineHungarian Academy of SciencesBudapestHungary
  2. 2.Department of AnesthesiologyMontefiore Medical Center/Albert Einstein College of MedicineBronxUSA

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