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The Potency and Time Course of the Neuromuscular Effects of SZ1676 and Its Hydroxy Analogs in Guinea-Pigs

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Muscle Relaxants

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Abstract

SZ 1676,1-[3α,17β-bis(acetyloxy)-2β-(1,4-dioxa-8-azaspiro[4, 5]dec-8-yl)-5α-androstan-l6β-yl]-1-(2-propenyl)pyrrolidinium.Br, and its 3-OH (SZ 1677), 17-OH (SZ 1824) and 3,17-OH (SZ1823) analogs are now being evaluated for eventual clinical use. In the present study the neuromuscular (NM) potencies and time courses of these compounds were compared to those of rocuronium. These studies were carried out on guinea-pigs (g.p.) because the relative potencies of steroid type muscle relaxants (MR) in clinical use were found to be relatively constant in g.p. and man1.

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References

  1. Foldes FF, Nitahara K, Kornak PH, Nagashima H. Anesthesiology 77:A930, 1992.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Montefiore Medical Center/Albert Einstein College of Medicine, 111 East 210th St., Bronx, NY, 10467-2490, USA

    Francis F. Foldes, Hideki Nakatsuka, Keiichi Nitahara, Katsunori Oe & Eiichiro Umeda

Authors
  1. Francis F. Foldes
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  2. Hideki Nakatsuka
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  3. Keiichi Nitahara
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  4. Katsunori Oe
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  5. Eiichiro Umeda
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan

    Kazuaki Fukushima M.D., Ph.D (Professor and Chairman) & Ryoichi Ochiai M.D., Ph.D (Professor and Chairman) & 

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© 1995 Springer Japan

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Foldes, F.F., Nakatsuka, H., Nitahara, K., Oe, K., Umeda, E. (1995). The Potency and Time Course of the Neuromuscular Effects of SZ1676 and Its Hydroxy Analogs in Guinea-Pigs. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_94

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  • DOI: https://doi.org/10.1007/978-4-431-66896-1_94

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-66898-5

  • Online ISBN: 978-4-431-66896-1

  • eBook Packages: Springer Book Archive

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