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The Potency and Time Course of the Neuromuscular Effects of SZ1676 and Its Hydroxy Analogs in Guinea-Pigs

  • Francis F. Foldes
  • Hideki Nakatsuka
  • Keiichi Nitahara
  • Katsunori Oe
  • Eiichiro Umeda
Conference paper

Abstract

SZ 1676,1-[3α,17β-bis(acetyloxy)-2β-(1,4-dioxa-8-azaspiro[4, 5]dec-8-yl)-5α-androstan-l6β-yl]-1-(2-propenyl)pyrrolidinium.Br, and its 3-OH (SZ 1677), 17-OH (SZ 1824) and 3,17-OH (SZ1823) analogs are now being evaluated for eventual clinical use. In the present study the neuromuscular (NM) potencies and time courses of these compounds were compared to those of rocuronium. These studies were carried out on guinea-pigs (g.p.) because the relative potencies of steroid type muscle relaxants (MR) in clinical use were found to be relatively constant in g.p. and man1.

Keywords

Sciatic Nerve Muscle Relaxant Relative Potency Tibialis Anterior Muscle Maximal Recovery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Foldes FF, Nitahara K, Kornak PH, Nagashima H. Anesthesiology 77:A930, 1992.CrossRefGoogle Scholar
  2. 2.
    Miller RD, Agoston S, Booij LHDJ et al. J Pharmac Exp Ther 207:539–43, 1978Google Scholar
  3. 3.
    Booij LHDJ, Vree TB, Hurkmans F et al. Der Anaesthesist 30:329–33, 1981.PubMedGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Francis F. Foldes
    • 1
  • Hideki Nakatsuka
    • 1
  • Keiichi Nitahara
    • 1
  • Katsunori Oe
    • 1
  • Eiichiro Umeda
    • 1
  1. 1.Department of AnesthesiologyMontefiore Medical Center/Albert Einstein College of MedicineBronxUSA

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