Advertisement

The Sensitivity of the Neonatal Rat to Mivacurium Relative to Mature Rats

  • H. S. Yang
  • N. G. Goudsouzian
  • J. A. J. Martyn
Conference paper

Abstract

Studies in humans have indicated differences in the dose-response curve for mivacurium between infants, children, and adults, but data in neonates and developing animals are not available.1-3 Previous studies with long acting relaxants have indicated that neonatal animals are sensitive to muscle relaxants.4 The present study, using the in vitro phrenic-hemidiaphragm preparation, elucidates the pharmacodynamic component of the agerelated altered dose-responses to mivacurium in postnatal rats.

Keywords

Muscle Relaxant Phrenic Nerve Neuromuscular Block Krebs Solution Neuromuscular System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Goudsouzian NG, Denman W, Schwartz A et al. Anesthesiology 79:919–925, 1993.PubMedCrossRefGoogle Scholar
  2. 2.
    Goudsouzian NG, Alifmoff J K, Eberly C et al. Anesthesiology 70:237–242, 1989.PubMedCrossRefGoogle Scholar
  3. 3.
    Sarner BJ, Brandom BW, Woelfel SK et al. Anesth Analg 68:116–121, 1989.PubMedCrossRefGoogle Scholar
  4. 4.
    Kelly SS, Roberts DV. Br J Anaesth 49:217–222, 1977.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • H. S. Yang
    • 1
  • N. G. Goudsouzian
    • 1
  • J. A. J. Martyn
    • 1
  1. 1.Department of Anesthesia, Harvard Medical SchoolMassachusetts General HospitalBostonUSA

Personalised recommendations