The Sensitivity of the Neonatal Rat to Mivacurium Relative to Mature Rats

  • H. S. Yang
  • N. G. Goudsouzian
  • J. A. J. Martyn
Conference paper


Studies in humans have indicated differences in the dose-response curve for mivacurium between infants, children, and adults, but data in neonates and developing animals are not available.1-3 Previous studies with long acting relaxants have indicated that neonatal animals are sensitive to muscle relaxants.4 The present study, using the in vitro phrenic-hemidiaphragm preparation, elucidates the pharmacodynamic component of the agerelated altered dose-responses to mivacurium in postnatal rats.


Muscle Relaxant Phrenic Nerve Neuromuscular Block Krebs Solution Neuromuscular System 
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  1. 1.
    Goudsouzian NG, Denman W, Schwartz A et al. Anesthesiology 79:919–925, 1993.PubMedCrossRefGoogle Scholar
  2. 2.
    Goudsouzian NG, Alifmoff J K, Eberly C et al. Anesthesiology 70:237–242, 1989.PubMedCrossRefGoogle Scholar
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    Sarner BJ, Brandom BW, Woelfel SK et al. Anesth Analg 68:116–121, 1989.PubMedCrossRefGoogle Scholar
  4. 4.
    Kelly SS, Roberts DV. Br J Anaesth 49:217–222, 1977.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • H. S. Yang
    • 1
  • N. G. Goudsouzian
    • 1
  • J. A. J. Martyn
    • 1
  1. 1.Department of Anesthesia, Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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