Pharmacodynamics of Pipecuronium in Patients with Decreased Renal Function

  • G. Mitterschiffthaler
  • F. K. Pühringer
Conference paper


In patients with impaired renal function Pipecuronium (Pip), a long acting relaxant, should not show a significantly prolonged effect, however the range of clinical duration is more variable [Canfell]. Aim of our study was to investigate if dose reduction according to glomerular filtration rate (GFR) and ideal body weight (IBW) varies the time course of action and the ranges.


Glomerular Filtration Rate Dose Reduction Impaired Renal Function Ideal Body Weight Prolonged Effect 
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  1. Cockcroft-Gault. Nephron (1976) 16:31CrossRefGoogle Scholar
  2. Canfell et al. Anesthesiology (1989) 70:7PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • G. Mitterschiffthaler
    • 1
  • F. K. Pühringer
    • 1
  1. 1.Department of Anesthesiology and General Intensive CareUniversity HospitalInnsbruckAustria

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