Approaches to Short-Acting Neuromuscular Blocking Agents
After almost fifty years suxamethonium is still widely used for a variety of short operations where rapid onset and short action are advantageous . Its drawbacks are well known and widely understood but it has long been recognised that a competitive agent with rapid onset and short action would be preferable. However, the rational design of any such agent depends on an ability to correlate these effects with particular aspects of chemical structure in a way that does not detract from the other essential requirements of a safe and effective neuromuscular blocking agent.
KeywordsNeuromuscular Blocking Neuromuscular Blocking Agent Neuromuscular Blocking Effect Vagal Blockade Competitive Agent
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