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Disposition of Mivacurium Isomers in Patients Undergoing Hypothermic Cardiopulmonary Bypass

  • Manfred Abel
  • Christoph Diefenbach
  • Gurean Aydincioglu
  • Martin Theisohn
  • Walter Buzello
Conference paper

Abstract

The muscle relaxant mivacurium (MIV), is made up of 3 isomers: trans-trans (tt; 55%), cis-trans (ct; 36%), and cis-cis (cc; 6%). Plasma cholinesterase (ChE) converts these compounds into 2 alcohol and 2 acid isomers. Hypothermic cardiopulmonary bypass (CPB) may be expected to impair these metabolic pathways by both reducing ChE activity and a direct effect of hypothermia. The present study was designed to analyse the disposition of the MIV isomers before, during and after CPB in the clinical setting.

Keywords

Plasma Concentration Muscle Relaxant Parent Compound Heart Surgery Neuromuscular Block 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Manfred Abel
    • 1
  • Christoph Diefenbach
    • 1
  • Gurean Aydincioglu
    • 1
  • Martin Theisohn
    • 1
  • Walter Buzello
    • 1
  1. 1.Department of AnesthesiaUniversity of CologneCologneGermany

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