Abstract
The muscle relaxant mivacurium (MIV), is made up of 3 isomers: trans-trans (tt; 55%), cis-trans (ct; 36%), and cis-cis (cc; 6%). Plasma cholinesterase (ChE) converts these compounds into 2 alcohol and 2 acid isomers. Hypothermic cardiopulmonary bypass (CPB) may be expected to impair these metabolic pathways by both reducing ChE activity and a direct effect of hypothermia. The present study was designed to analyse the disposition of the MIV isomers before, during and after CPB in the clinical setting.
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© 1995 Springer Japan
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Abel, M., Diefenbach, C., Aydincioglu, G., Theisohn, M., Buzello, W. (1995). Disposition of Mivacurium Isomers in Patients Undergoing Hypothermic Cardiopulmonary Bypass. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_86
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DOI: https://doi.org/10.1007/978-4-431-66896-1_86
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-66898-5
Online ISBN: 978-4-431-66896-1
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