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Postsynaptic Nicotinic Receptor Desensitized by Non-Contractile Ca2+ Mobilization (Ramic) via Protein Kinase-C Activation at the Mouse Neuromuscular Junction

  • Ikuko Kimura
  • Katsuya Dezaki
  • Hiroshi Tsuneki
  • Masayasu Kimura
Conference paper

Abstract

RAMIC (receptor-activity modulating intracellular Ca2+) is mobilized by nerve stimuli after acetylcholinesterase inhibition at the neuromuscular junction, without accompanying muscle contraction. The RAMIC mobilization is closely related to Ca2+ influx through nicotinic acetylcholine receptor (nAChR) channel and is independent of contractile Ca2+ released from sarcoplasmic reticulum. We investigated the functional role of RAMIC in the process of nAChR desensitization.

Keywords

Sarcoplasmic Reticulum Neuromuscular Junction Nicotinic Acetylcholine Receptor Acetylcholinesterase Inhibition Pulse Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Ikuko Kimura
    • 1
  • Katsuya Dezaki
    • 1
  • Hiroshi Tsuneki
    • 1
  • Masayasu Kimura
    • 1
  1. 1.Department of Chemical Pharmacology, Faculty of Pharmaceutical SciencesToyama Medical and Pharmaceutical UniversityToyamaJapan

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