Comparative Studies of Pipecuronium and Tubocurarine on Releases of Histamine and N-Methylhistamine in Surgical Patients
It has been reported that there is no evidence of plasma histamine (HA) release by the intravenous administration of pipecuronium (PPB) in humans(1). It is well recognized that the half life of released plasma histamine (HA) is very short but that of n-methylhistamine (n-MHA) , a metabolite, is much longer. Assaying both HA and n-MHA would reveal the extent to which HA appears in plasma. This study was undertaken to assess pipecuronium (PPB) induced release of HA compared with tubocurarine (d-Tc) by measuring both HA and n-MHA in plasma.
KeywordsPublic Health Blood Pressure Heart Rate Blood Sample Informed Consent
- 1).Brit.J.Anaesth 1991:67:320Google Scholar