Female Rats are More Sensitive to the Neuromuscular Blocking Action of Rocuronium than Male Rats
Potency (1), being the result of pharmacokinetics and pharmacodynamics, and sensitivity (intrinsic potency) (2), which is based solely on pharmacodynamics, have been reported to differ for NMBAs between male and female patients. Although gender has been reported to have a clear impact on pharmacokinetics of several drugs (3), pharmacokinetic data on NMBAs are inconsistent with respect to the influence of gender on the neuromuscular blocking response. We investigated the influence of gender on the sensitivity of rocuronium in rats under pseudo steady state conditions, i.e. stable block under unchanged infusion rates for over 15 min.