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Female Rats are More Sensitive to the Neuromuscular Blocking Action of Rocuronium than Male Rats

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Book cover Muscle Relaxants

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Abstract

Potency (1), being the result of pharmacokinetics and pharmacodynamics, and sensitivity (intrinsic potency) (2), which is based solely on pharmacodynamics, have been reported to differ for NMBAs between male and female patients. Although gender has been reported to have a clear impact on pharmacokinetics of several drugs (3), pharmacokinetic data on NMBAs are inconsistent with respect to the influence of gender on the neuromuscular blocking response. We investigated the influence of gender on the sensitivity of rocuronium in rats under pseudo steady state conditions, i.e. stable block under unchanged infusion rates for over 15 min.

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References

  1. Parker et al. Br J Anaesth 69, 439, 1992.

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  2. Beemer GH, Bjorksten AR, Anesth Analg 76, 1288, 1993.

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  3. Giudicelli JF, Tillement JP, Clin Pharmacokin 2, 157, 1977.

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Author information

Authors and Affiliations

  1. Servizio di Anestesia e Rianimazione, Ospedale Civile, 23100, Sondrio, Italy

    E. Maestrone

  2. Research Group for Experimental Anesthesiology and Clinical Pharmacology, University of Groningen, The Netherlands

    R. H. Henning, M. C. Houwertjes & J. M. K. H. Wierda

Authors
  1. E. Maestrone
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  2. R. H. Henning
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  3. M. C. Houwertjes
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  4. J. M. K. H. Wierda
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Editor information

Editors and Affiliations

  1. Department of Anesthesiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan

    Kazuaki Fukushima M.D., Ph.D (Professor and Chairman) & Ryoichi Ochiai M.D., Ph.D (Professor and Chairman) & 

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© 1995 Springer Japan

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Maestrone, E., Henning, R.H., Houwertjes, M.C., Wierda, J.M.K.H. (1995). Female Rats are More Sensitive to the Neuromuscular Blocking Action of Rocuronium than Male Rats. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_67

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  • DOI: https://doi.org/10.1007/978-4-431-66896-1_67

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-66898-5

  • Online ISBN: 978-4-431-66896-1

  • eBook Packages: Springer Book Archive

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