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Female Rats are More Sensitive to the Neuromuscular Blocking Action of Rocuronium than Male Rats

  • E. Maestrone
  • R. H. Henning
  • M. C. Houwertjes
  • J. M. K. H. Wierda
Conference paper

Abstract

Potency (1), being the result of pharmacokinetics and pharmacodynamics, and sensitivity (intrinsic potency) (2), which is based solely on pharmacodynamics, have been reported to differ for NMBAs between male and female patients. Although gender has been reported to have a clear impact on pharmacokinetics of several drugs (3), pharmacokinetic data on NMBAs are inconsistent with respect to the influence of gender on the neuromuscular blocking response. We investigated the influence of gender on the sensitivity of rocuronium in rats under pseudo steady state conditions, i.e. stable block under unchanged infusion rates for over 15 min.

Keywords

Netherlands Introduction Stable Block Force Displacement Transducer Determine Plasma Concentration Gender Conc 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1).
    Parker et al. Br J Anaesth 69, 439, 1992.PubMedCrossRefGoogle Scholar
  2. 2).
    Beemer GH, Bjorksten AR, Anesth Analg 76, 1288, 1993.PubMedGoogle Scholar
  3. 3).
    Giudicelli JF, Tillement JP, Clin Pharmacokin 2, 157, 1977.CrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • E. Maestrone
    • 1
  • R. H. Henning
    • 2
  • M. C. Houwertjes
    • 2
  • J. M. K. H. Wierda
    • 2
  1. 1.Servizio di Anestesia e RianimazioneOspedale CivileSondrioItaly
  2. 2.Research Group for Experimental Anesthesiology and Clinical PharmacologyUniversity of GroningenThe Netherlands

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