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Time Course of Neuromuscular Block of Vecuronium Analogues and d-Tubocurarine in the Chick Biventer Cervicis Muscle

  • Joanna M. Ward
  • Hassan Fajrak
  • Chris Prior
Conference paper

Abstract

The effects of the steroidal muscle relaxants vecuronium, rocuronium and Org 9487, and some of their metabolites have been investigated on the in vitro chick biventer cervicis muscle preparation. Muscles were removed from 4–10 day old chicks (Ginsborg & Warriner, 1961), mounted in 10 ml tissue baths in Krebs-Henseleit solution (32°C, pH 7.3) and bubbled with oxygen containing 5 % CO2. Twitches were evoked at 0.1 Hz with pulses of 0.1 ms duration and supramaximal voltage. After administration of a concentration of drug giving between 70–90 % block, the drug was allowed to remain in contact with the tissue for 90 minutes.

Keywords

Neuromuscular Blocking Blocking Drug Muscle Preparation Partial Restoration Original Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Ginsborg, B.L. & Warriner, J. (1960) Br. J. Pharmacol. 15, 410–415.Google Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Joanna M. Ward
    • 1
  • Hassan Fajrak
    • 1
  • Chris Prior
    • 1
  1. 1.Department of Physiology and PharmacologyUniversity of StrathclydeGlasgowUK

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