Influence of Bambuterol on the Duration of Action of Mivacurium Induced Neuromuscular Blockade
Mivacurium has a short duration of action due to its rapid hydrolysis by plasma cholinesterase (pChe) (1). Bambuterol (the bis-dimethylcarbamate prodrug of terbutaline) is a new bronchodilator intended for oral use. It is metabolised in the liver and by pChe. However, as the two carbamate groups in the molecule inhibit the pChe, the metabolism is slow and the duration of action prolonged (2). The purpose of this study was to evaluate the effect of Bambuterol on pChe activity and the neuromuscular block following mivacurium.