Griffith and Johnson’s original description  of the use of tubocurarine shows them to have had an anticholinesterase available but not to have used it. Their patients did not need artificial ventilation and appeared to suffer no ill effects. But when I started training in the early 1960’s the doses used were greater, artificial ventilation was almost universal when relaxants were used as were anticholinesterases — and some patients showed the problem of ’neostigmine-resistant curarization’. Beecher and Todd’s study  implicated relaxants as a cause of death. Harrison  claimed that some twenty percent of deaths associated with anaesthesia were due to the misuse of relaxants.
KeywordsNeuromuscular Blockade Artificial Ventilation Maximum Inspiratory Pressure Residual Block Double Burst Stimulation
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