Problems with Reversal in Adults

  • J. Norman
Conference paper


Griffith and Johnson’s original description [1] of the use of tubocurarine shows them to have had an anticholinesterase available but not to have used it. Their patients did not need artificial ventilation and appeared to suffer no ill effects. But when I started training in the early 1960’s the doses used were greater, artificial ventilation was almost universal when relaxants were used as were anticholinesterases — and some patients showed the problem of ’neostigmine-resistant curarization’. Beecher and Todd’s study [2] implicated relaxants as a cause of death. Harrison [3] claimed that some twenty percent of deaths associated with anaesthesia were due to the misuse of relaxants.


Neuromuscular Blockade Artificial Ventilation Maximum Inspiratory Pressure Residual Block Double Burst Stimulation 
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Copyright information

© Springer Japan 1995

Authors and Affiliations

  • J. Norman
    • 1
  1. 1.Department of Anaesthetics, Southampton General HospitalUniversity of SouthamptonSouthamptonUK

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