Abstract
Rocuronium (Org 9426), which has recently been introduced in clinical practice, is the 2-morpholino, 3-hydroxy, 16N-allyl-pyrrolidino derivative of vecuronium. In contrast to vecuronium no pharmacologically active metabolites of this compound have been found in man. Its neuromuscular blocking potency is about 7 times less than that of vecuronium [1,2]. Rocuronium has intermediate duration of action, and after several maintenance doses of rocuronium no tendency toward cumulation was shown [3,4]. Therefore, rocuronium might be suitable for prolonged administration in critically ill patients (ICU-patients). However, neuromuscular blocking agents are developed and tested for use once or twice in a life-time, usually in surgical patients. No information has been available so far on the administration of rocuronium in critically ill patients .
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© 1995 Springer Japan
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Sparr, H.J., Khuenl-Brady, K.S., Puehringer, F.K., Kolbitsch, C., Agoston, S. (1995). Pharmacodynamics and Pharmacokinetics of Different Modes of Rocuronium Administration. In: Fukushima, K., Ochiai, R. (eds) Muscle Relaxants. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66896-1_43
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DOI: https://doi.org/10.1007/978-4-431-66896-1_43
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