Pharmacodynamics and Pharmacokinetics of Different Modes of Rocuronium Administration

  • H. J. Sparr
  • K. S. Khuenl-Brady
  • F. K. Puehringer
  • Ch. Kolbitsch
  • S. Agoston
Conference paper


Rocuronium (Org 9426), which has recently been introduced in clinical practice, is the 2-morpholino, 3-hydroxy, 16N-allyl-pyrrolidino derivative of vecuronium. In contrast to vecuronium no pharmacologically active metabolites of this compound have been found in man. Its neuromuscular blocking potency is about 7 times less than that of vecuronium [1,2]. Rocuronium has intermediate duration of action, and after several maintenance doses of rocuronium no tendency toward cumulation was shown [3,4]. Therefore, rocuronium might be suitable for prolonged administration in critically ill patients (ICU-patients). However, neuromuscular blocking agents are developed and tested for use once or twice in a life-time, usually in surgical patients. No information has been available so far on the administration of rocuronium in critically ill patients .


Surgical Patient Neuromuscular Blocking Agent Infusion Group Peripheral Nerve Stimulator Rocuronium Bromide 
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Copyright information

© Springer Japan 1995

Authors and Affiliations

  • H. J. Sparr
    • 1
  • K. S. Khuenl-Brady
    • 1
  • F. K. Puehringer
    • 1
  • Ch. Kolbitsch
    • 1
  • S. Agoston
    • 1
    • 2
  1. 1.Department of Anaesthesia and Intensive Care MedicineUniversity of InnsbruckInnsbruckAustria
  2. 2.Research Group on Experimental Anaesthesiology and Clinical Pharmacology, Department of AnaesthesiologyUniversity HospitalGroningenThe Netherlands

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