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The Pharmacokinetics of the Three Isomers of Mivacurium Chloride in Healthy, Renal and Hepatic Patients Given Short or Prolonged Infusions of the Drug

  • Jennifer M. Hunter

Abstract

A solution of mivacurium chloride contains a mixture of three non-interchangeable stereoisomers; trans-trans (57%), cis-trans (37%) and cis-cis (6%)[1]. The trans-trans and cis-trans isomers are thought to have a very short duration of action of only a few minutes; the cis-cis isomer has a longer effect, of at least 30 min, but has only about one tenth of the neuromuscular blocking potency of the other two isomers.

Keywords

Cirrhotic Patient Constant Infusion Cholinesterase Activity Renal Failure Patient Prolonged Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Jennifer M. Hunter
    • 1
  1. 1.Department of AnaesthesiaRoyal Liverpool University HospitalLiverpoolUK

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