The Pharmacokinetics of the Three Isomers of Mivacurium Chloride in Healthy, Renal and Hepatic Patients Given Short or Prolonged Infusions of the Drug
A solution of mivacurium chloride contains a mixture of three non-interchangeable stereoisomers; trans-trans (57%), cis-trans (37%) and cis-cis (6%). The trans-trans and cis-trans isomers are thought to have a very short duration of action of only a few minutes; the cis-cis isomer has a longer effect, of at least 30 min, but has only about one tenth of the neuromuscular blocking potency of the other two isomers.
KeywordsCirrhotic Patient Constant Infusion Cholinesterase Activity Renal Failure Patient Prolonged Infusion
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