Pharmacokinetics and Pharmacodynamics of Aminosteroidal Neuromuscular Blocking Agents and Their Metabolites
With the refinement of analytical methods for aminostero idal neuromuscular blocking agents using gas chromatography and mass spectroscopy(1), it is becoming increasingly important to analyze the parent compound as well as their metabolites in evaluating the pharmacokinetics and pharmacodynamics of these agents. Much evidence is coming out demonstrat ing, for example, that 3-OH vecuronium is playing an important role in the neuromuscular blocking action of vecuronium when it is given for a long time or to patients with compromised organs(2,3).
KeywordsNeuromuscular Blockade Bolus Administration Neuromuscular Blocking Agent Prolonged Neuromuscular Blockade Pharmacokinetic Simulation
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