Structure-Pharmacokinetic and Pharmacodynamic Relationships of Steroidal Neuromuscular Blocking Agents

  • Johannes H. Proost
  • J. Mark K. H. Wierda
  • Dirk K. F. Meijer


In anesthesiology there is still a need for a short-acting non-depolarizing neuromuscular blocking agent (NMBA) for intubation, replacing the depolarizing agent suxamethonium. In order to find a rational basis for the development of new short-acting NMBA’s, it is essential to know the factors governing the time course of action of this class of drugs.


Onset Time Plasma Protein Binding Quaternary Ammonium Compound Neuromuscular Blocking Agent Effect Compartment 
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Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Johannes H. Proost
    • 1
    • 2
  • J. Mark K. H. Wierda
    • 1
    • 2
  • Dirk K. F. Meijer
    • 1
    • 2
  1. 1.Department of Pharmacology and TherapeuticsUniversity Centre for PharmacyGroningenThe Netherlands
  2. 2.Research Group for Experimental Anesthesiology and Clinical PharmacologyUniversity HospitalGroningenThe Netherlands

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