Conceptual Building Blocks in Developing a Pharmacodynamic Model for a Muscle Relaxant

  • Vladimir Nigrovic
  • Ashraf Banoub
Conference paper


A pharmacodynamic model for any drug is an artificial construct intended to simulate the course of action of that drug over time. We present the concepts involved in building such a model for nondepolarizing neuromuscular blocking agents using physiologic and pharmacologic principles. The advantages of this model are: (i) simplicity, (ii) the possibility to apply the model to any nondepolarizing muscle relaxant, and (iii) clarity in understanding each individual parameter used in the model.


Muscle Relaxant Interstitial Space Nicotinic Receptor Neuromuscular Block Receptor Occupancy 
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Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Vladimir Nigrovic
    • 1
  • Ashraf Banoub
    • 1
  1. 1.Departments of Anesthesiology and PharmacologyMedical College of OhioToledoUSA

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