Metabolism and Metabolites of Benzylisoquinolinium Diester Compounds
Diester onium compounds, generically, are synthesized as potential substrates for plasma esterases including pseudocholinesterase, or as candidates for the non-biological chemical degradation of quaternary ammonium compounds known as the Hofmann elimination. The benzylisoquinolinium diesters are metabolized or degraded by either mechanism, depending on specific structural requirements.
KeywordsQuaternary Ammonium Compound Amino Alcohol Hydrolytic Pathway Mivacurium Chloride Plasma Esterase
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