Mechanisms — Changes Induced by Long-Term High-Dose Muscle Relaxant Administration
Over 95% of the literature describes the use of muscle relaxants in patients undergoing surgery even though doses, ranging from five to 100 times larger than that used in the operating room, are used in the ICU. These large doses far exceed those described in the package insert. Furthermore, these large doses are given to ICU patients who are frequently much sicker than those in the operating room. Yet, the literature is rather sparse regarding the use of muscle relaxants in the ICU.