Kinetic-Dynamic Modelling of Neuromuscular Blockade
Pharmacokinetics describe the disposition of drug within the body. Yet this description alone is meaningless without implications of its consequences on drug activity; in the case of the neuromuscular blocking agents (NMBAs), on the time-course of paralysis. Kineticdynamic modelling uses the nonlinear relationships of plasma pharmacokinetics as the forcing function for the drug concentrations in a hypothetical effect compartment.
KeywordsNeuromuscular Blockade Sigmoid Curve Neuromuscular Blocking Agent Effect Compartment Recovery Index
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