Kinetic-Dynamic Modelling of Neuromuscular Blockade

  • C. Shanks
Conference paper


Pharmacokinetics describe the disposition of drug within the body. Yet this description alone is meaningless without implications of its consequences on drug activity; in the case of the neuromuscular blocking agents (NMBAs), on the time-course of paralysis. Kineticdynamic modelling uses the nonlinear relationships of plasma pharmacokinetics as the forcing function for the drug concentrations in a hypothetical effect compartment.


Neuromuscular Blockade Sigmoid Curve Neuromuscular Blocking Agent Effect Compartment Recovery Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Sheiner LB, Stanski DR, Vozeh S, Miller RD, Ham J. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 25:358–371, 1979.PubMedGoogle Scholar
  2. 2.
    Shafer SL, Varvel JR, Gronert GA. A comparison of parametric with semiparametric analysis of concentration versus effect relationship of metocurine in dogs and pigs. J Pharmacokin Biopharm 17:291–304, 1989.CrossRefGoogle Scholar
  3. 3.
    Matteo RS, Ornstein E, Schwartz AE, Ostapovich N, Stone JG. Pharmacokinetics and pharmacodynamics of rocuronium (ORG 9426) in elderly surgical patients. Anesth Analg 77:1193–1197, 1993.PubMedCrossRefGoogle Scholar
  4. 4.
    Law Min J-C, Hood J, Campkin N, Feldman S. Recovery of atracurium and vecuronium neuromuscular block in the isolated forearm. Brit J Anaesth 71:730–731, 1993.CrossRefGoogle Scholar
  5. 5.
    Fawcett WJ, Fauvel NJ, Feldman SA. Comparison of recovery index of rocuronium or vecuronium with simultaneously administered pancuronium in the isolated forearm. Anaesthesia 48:200–201, 1993.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • C. Shanks
    • 1
  1. 1.Department of AnesthesiaNorthwestern UniversityChicagoUSA

Personalised recommendations