Neuromuscular Interaction Between Succinylcholine and Esmolol in the Rat
Esmolol, an ultra-short-acting beta-receptor blocking agent, has been used during intubation to prevent hyperadrenergic response of hypertension and tachycardia in surgical patients. It is inactivated by the esterase. However, succinylcholine (SDC) is used to faciliate tracheal intubation during induction of anesthesia and metabolized by plasma cholinesterase. This study is designed to evaluate the neuromuscular interactions between SDC and esmolol in the rat.