Mivacurium-Induced Neuromuscular Blockade (NB) Is Not Affected by Chronic Anticonvulsant Therapy with Carbamazepine

  • A. Spacek
  • F. X. Neiger
  • R. L. Katz
  • W. D. Watkins
  • C. K. Spiss
Conference paper


Patients chronically receiving carbamazepine are known to be resistant to nondepolarizing muscle relaxants: vecuronium (1), pancuronium (2) and doxacurium (3). This effect does not apply to atracurium (4). The present study was designed to investigate the influence of carbamazepine on NB of mivacurium in neurosurgical patients.


Pulse Oximetry Neuromuscular Blockade Neurosurgical Patient Plasma Drug Level Recovery Index 
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Copyright information

© Springer Japan 1995

Authors and Affiliations

  • A. Spacek
    • 1
  • F. X. Neiger
    • 2
  • R. L. Katz
    • 3
  • W. D. Watkins
    • 4
  • C. K. Spiss
    • 2
  1. 1.Departments of Anesthesia and General Intensive Care AUniversity of ViennaViennaAustria
  2. 2.Departments of Anesthesia and General Intensive Care BUniversity of ViennaViennaAustria
  3. 3.Department of AnesthesiologyUCLA School of MedicineLos AngelesUSA
  4. 4.Department of Anesthesiology, CCMUniversity of Pittsburgh Medical CenterPittsburghUSA

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