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Dose Response Relationship of Mivacurium in Patients Homozygous for the Atypical Cholinesterase Gene

  • Doris Østergaard
  • Frank S. Jensen
  • Lene Theil Skovgaard
  • Jørgen Viby-Mogensen
Conference paper

Abstract

Mivacurium is rapidly hydrolysed by plasma cholinesterase (pChe) (1). In patients homozygous for the atypical gene the duration of action of mivacurium is prolonged (2). The purpose of this study was to determine the potency of mivacurium in patients homozygous for the atypical gene by constructing dose-response curves.

Keywords

Dose Response Relationship Neuromuscular Block Maximum Suppression Probit Regression Incremental Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    J.J. Savarese et al., Anesthesiology 68: 723–32, 1988PubMedCrossRefGoogle Scholar
  2. 2.
    D. Østergaard et al., Acta Anaesth Scand 37: 315–319, 1992Google Scholar
  3. 3.
    C.E. Smith et al., Anesthesiology 70: 156–158, 1989.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1995

Authors and Affiliations

  • Doris Østergaard
    • 1
    • 2
  • Frank S. Jensen
    • 1
    • 2
  • Lene Theil Skovgaard
    • 1
    • 2
  • Jørgen Viby-Mogensen
    • 1
    • 2
  1. 1.Danish Cholinesterase Research UnitThe National University Hospital, RigshospitaletCopenhagenDenmark
  2. 2.Statistical Research Unit, Panum Institute and Department of AnesthesiaGentofte HospitalCopenhagenDenmark

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