We have had good discussions about brain hypothermia treatment, arising from information both from experimental animal studies and from clinical trials. There is no doubt as to the effectiveness of neuroprotection from ischemic insults provided by brain hypothermia as shown in animal studies. However, in clinical studies, similar effects to animal studies have not been obtained. The benefits of hypothermia are still controversial in clinical trials of hypothermia treatment. Why are such differences recorded between animal studies and clinical results? I want to summarize the answers to this question. This answer will include the basic concept of brain hypothermia treatment in survival of patients with severe brain injuries.
KeywordsBrain Injury Cerebral Perfusion Pressure Cooling Stage Severe Brain Injury Injured Neuron
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