Summary
As emergency and intensive care medicine progresses, brain hypothermia is attracting attention as a therapeutic method that overcomes the hmitations of cerebral protection and resuscitation. We conducted a preliminary study by preparing a protocol of mild hypothermia by coil cooling at 34°C in patients who returned to spontaneous circulation via standard advanced cardiac life support and had experienced out-of-hospital ventricular fibrillation (VF) due to suspected cardiac arrest. Primary endpoints were survival at hospital discharge and good recovery using the Glasgow Outcome Scale. This study was performed in 15 patients meeting the inclusion criteria of mild hypothermia. The average core temperature during mild hypothermia at the cooling stage was 34.4°C, and the average duration was 83.9h. Survival rate at hospital discharge was 80%, and the good recovery rate was 67%. Multivariate analysis revealed that systemic oxygen delivery at the cooling stage was an indepedent predictor of good recovery. In conclusion, brain hypothermia (at a temperature of 34°C for 3 days and by coil cooling) in comatose survivors with out-of-hospital VF may have improved the outcome.
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Nagao, K., Hayashi, N., Arima, K., Kikushima, K., Ohtsuki, J., Kanmatsuse, K. (2000). Mild Hypothermia for Cerebral Resuscitation in Survivors of Out-of-Hospital Ventricular Fibrillation. In: Hayashi, N. (eds) Brain Hypothermia. Springer, Tokyo. https://doi.org/10.1007/978-4-431-66882-4_19
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DOI: https://doi.org/10.1007/978-4-431-66882-4_19
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