Summary
New heparin-immobilized polyurethaneurea surfaces utilizing hydrophilic spacer systems have been developed for in situ surface modification. Surface modification both by hydrophilic grafting of polyethylene oxide (PEO) and PEO-heparin as well as by heparinized amphiphilic block copolymer coatings significantly improves the nonthrombogenicity of the polyurethaneurea surface without changing the bulk mechanical properties. Heparin immobilization by grafting and coating provides levels of bioactivity that are successful in suppressing contact activation of the intrinsic cascade as well as inhibiting platelet adhesion in vitro. Ex vivo evaluation of these systems in whole blood shunts under conditions of low flow rate and low shear show an impressive ability of immobilized heparin to prolong shunt patency over control materials.
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© 1988 Springer Japan
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Okano, T., Grainger, D., Park, K.D., Nojiri, C., Feijen, J., Kim, S.W. (1988). Improved blood compatibility of heparin immobilization and PEO-PDMS-heparin triblock copolymer coating on surfaces of segmented polyurethaneurea. In: Akutsu, T., et al. Artificial Heart 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65964-8_6
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DOI: https://doi.org/10.1007/978-4-431-65964-8_6
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-70544-4
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