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Blood material interactions: Ex vivo investigations of polyurethanes

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Artificial Heart 2

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Summary

A canine ex vivo series shunt was utilized to evaluate short-term blood compatibility of polyurethane block copolymers. The series shunt allows the evaluation of up to ten different materials simultaneously. Deposition of radiolabeled platelets and fibrinogen is quantified and used as a measure of thrombogenicity. The canine ex vivo experiment has been implemented in investigations of the roles of many aspects of polymer surface chemistry in platelet-surface and protein-surface interactions. This paper reviews some significant, recent results. The extent of microphase separation in polyurethane block copolymers has been found to affect surface properties and platelet-surface interactions. In addition, derivatization strategies for polyurethanes have been developed that enhance the specific adsorption of albumin, a surface passivating protein, and affect thrombogenicity as measured in the canine ex vivo model.

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Author information

Authors and Affiliations

  1. Department of Chemical Engineering, University of Wisconsin, 1415 Johnson Drive, Madison, WI, 53706, USA

    Timothy G. Grasel

Authors
  1. Stuart L. Cooper
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  2. Thomas A. Giroux
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  3. Timothy G. Grasel
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Editor information

Editors and Affiliations

  1. National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565, Japan

    Tetsuzo Akutsu M.D., Ph.D. (Vice-Director) (Vice-Director)

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© 1988 Springer Japan

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Cooper, S.L., Giroux, T.A., Grasel, T.G. (1988). Blood material interactions: Ex vivo investigations of polyurethanes. In: Akutsu, T., et al. Artificial Heart 2. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65964-8_1

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  • DOI: https://doi.org/10.1007/978-4-431-65964-8_1

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-70544-4

  • Online ISBN: 978-4-431-65964-8

  • eBook Packages: Springer Book Archive

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