Summary
The extensive diversification of limb morphologies during arthropod evolution has aided the spread of new species to distant locations and adaptation for distinct niches. Functional evolution of homeotic genes is thought to have played a key role in this diversification process, but the molecular mechanisms underlying this process remain to be elucidated. Insects and crustaceans are close relatives within arthropods and possess a variety of diversities in the shape of their limbs. Comparison of genetic circuitries underlying the formation of insect and crustacean limbs should reveal the genetic history of their morphological evolution. We have recently analyzed the functional role of ANTENNAPEDIA (ANTP) homeotic protein of the crustacean Daphnia magna and compared its properties to its weil studied counterpart, the insect Drosophila melanogaster.Our results suggest that highly restricted expression of ANTP in the first leg of Daphnia specifies its morphology. Furthermore, while the core ANTP function of specifying thoracic identity is conserved, changes in the protein region outside of the homeodomain altered the target gene specificity. Based on these findings, we discuss the role of homeotic gene evolution in diversification of arthropod limb morphology.
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References
Abzhanov, A. and Kaufman, T.C. (2000). Crustacean (malacostracan) Hox genes and the evolution of the arthropod trunk. Development, 127: 2239–2249.
Abzhanov, A. and Kaufman,T.C. (2000). Embryonic expression patterns of the Hox genes of the crayfish Procambarus clarkii (Crustacea, Decapoda), Evol Dev, 2: 271–283.
Averof, M. and Akam, M. (1995): Hox genes and the divers and crustacean body plans. Nature, 376:420–423.
Averof, M. and Patel, N.H. (1997). Crustacean appendage evolution associated with changes in Hox gene expression. Nature, 388:682–686:
Bermingham, J.R.J. and Scott, M.P. (1988). Developmentally regulated alternative splicing of transcripts from the Drosophila homeotic gene Antennapedia can produce four different proteins. EMBO J., 7: 3211–3222.
Brusca, R.C. and Brusca; G.J. (1990). Invertebrates. Sinauer Associates, inc., Sunderland, Massachusetts.
Carroll, S., Grenier, J. and Weatherbee, S. (2001). From DNA to Diversity-Molecular Genetics and the Evolution of Animal Design,Blackwell Science Inc.
Casares,F. and Mann, R.S., (1998). Control of antenna], versus leg development in Drosophila. Nature, 392:723–726
Fasano, L., Rder,L.,Core N., Alexandre, E., Vola, C., Jacq, B. and Kerridge, S. (1991). The teashirt gene is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs. Cell, 64: 63–79.
Galant, R. and Carroll, S.B. (2002), Evolution of a transcriptional repression domain in an insect Hox protein. Nature, 415: 910–3.
Grenier; J.K., Garber, T.L., Warren, R., Whitington, P.M.and Carroll, S. (1997). Evolution of the entire arthropod Hox gene set predated the origin and adiation of the onychophoran/arthropod clade. Curr Biol, 7: 547–553.
Jaffe, L., Ryoo, H.D. and Mann, R.S. (1997). A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila. Genes Dev, 11: 1327–1340.
Kelsh, R., Weinzierl, R.O., White, R.A. and Akam, M. (1994). Homeotic-gene expression in the locust Schistocerca: an antibody that detects conserved epitopes in Ultrabitlorax and abdominal-A’ proteins. Dey Genet, 15: 19–31.
Krumlauf, R. (1992). Evolution of the vertebrate Hox homeobox genes. Bioes-says, 14: 245–52.
Li, X. and McGinnis, W. (1999). Activity regulation of Hox proteins, a mechanism for altering functional, specificity in development and evolution. Proc atl` Acad Sci U S A, 96: 6802–7.
Malicki, J., Schughart, K., McGinnis, W. (1990). mouse Hox-2.2 specifies tho racic segmental identity in Drosophila embryo and larvae.Cell, 63: 961–967.
Morata, G. (1993). Homeotic genes of Drosophila. Curr Opin Genet Dev, 3: 606–614.
Panganiban, G., Irvine, S.M., Lowe, C., Roehl, H., Corley, L.S.,Sherbon, B., Grenier, J.K., Fallon, J.F., Kimble, J. and Walker, M. (1997). The origin and evolution of animal appendages. Proc Natl Acad Sci U S A, 94: 5162–5166.
Panganiban, G., Sebring, A., Nagy, L. and Carroll. S (1995). The development of crustacean limbs and the evolution of arthropods. Science, 270: 1363–1366.
Ronshaugen, M., McGinnis, N. and McGinnis, W. (2002), Hol protein mutation and macroevolution of the insect body plan. Nature, 415:914–7
Schneuwly, S., Klemenz, R. and Gehring, W.J. (1987): Redesigr.ing the body plan of Drosophila by ectopic expression of the hornoeotiç gene Antennapedia. Nature, 325: 816–818.
Shiga, Y., Yasurroto, R., Yamagata, H. and Hayashi, S. (2002). Evolving role of Antennapedia protein in arthropod limb patterning.,DevélöPmemt, 129: 3555–61.
Strunl, G. (1981). A homceotic mutation transforming leg to antenna in Drosophila. Nature, 292: 635–8.
Vacnon? G., Cohen, B., Pfeifle, C., McGuffir, M.E., Botas, J. and Cohen, S.M. (1992). Homeotic genes in of the bithorax complex repress lirnb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell,71: 437–450.
Warren, R.W.,Nagy, L., Seleguz, J., Gates, J. and Carroll, S. (1994). Evolution of homeotic gene régulation and function in flies and butterflies. Nature, 372: 458–461.
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Hayashi, S., Yamagata, H., Shiga, Y. (2003). Changing Roles of Homeotic Gene Functions in Arthropod Limb Development. In: Sekimura, T., Noji, S., Ueno, N., Maini, P.K. (eds) Morphogenesis and Pattern Formation in Biological Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-65958-7_7
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DOI: https://doi.org/10.1007/978-4-431-65958-7_7
Publisher Name: Springer, Tokyo
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