Pattern Formation by Cell Movement in Closely-Packed Tissues
Cell movement in 3-dimensional tissues is important in various biological processes such as cell-sorting, wound healing, and metastasis. Unlike solitary cells attached to a fiat surface, motile cells tightly packed in 3-dimensional tissues are under strong mechanical constraints, but nevertheless they can still move actively by getting traction from the neighbouring cells. Here, I will describe some characteristics of cell movements in isolation and within multicellular tissues in the cellular slime mould Dictyostelium, and propose a possible mechanism whereby the cells inside a tissue can get traction from the substratum. Based on this hypothesis, models for cell sorting and for the generation of coherent motion of cells in tissues will also be outlined.
KeywordsDictyostelium Discoideum Coherent Motion Dictyostelium Cell Myosin Heavy Chain Gene Cortical Tension
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